CP61
CP61 is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH binding, disrupting the NADH-dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation. CP61 can be used in breast cancer research.
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- No. CAS: 1631984-43-4
- Fòrmula: C50H73N13O12S
- Peso molecular:1080.26
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
CtBP1 |
CtBP2 |
In Vitro
CP61 acetate disrupts the NADH-dependent homodimerization of CtBP1[1].
CP61 acetate inhibits CtBP2 homodimerization with an IC50 of 19 μM in ELISA assays[1].
CP61 acetate disrupts CtBP1 dimerization in a dose-dependent manner[1].
CP61 acetate inhibits NADH binding to CtBP1 through an allosteric mechanism and binds to dimeric CtBP1 with an affinity of 3-11 μM[1].
CP61 (50 μM) acetate increases abnormal mitosis and prolongs mitotic duration in synchronized MCF-7 cells[1].
CP61 (50 μM) acetate selectively increases abnormal mitosis and prolongs mitotic duration in highly glycolytic MCF-7 cells, but has no such effect in MDA-MB-453 cells with lower glycolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7
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Concentration:50 μM
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Incubation Time:48 h
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Result:Did not affect the protein abundance of CtBP1 or CtBP2 in MCF-7 cells when treated with CP61-TAT.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Soft Agar Colony Formation Assay
- MTT Cell Proliferation Assay
- Genotoxicity/Mutagenicity Study
Chemical Information
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No. CAS 1631984-43-4
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Peso molecular 1080.26
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Fòrmula C50H73N13O12S
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Sequence
cyclo(Ser-Gly-Trp-Thr-Val-Val-Arg-Met-Tyr)
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Sequence Shortening
cyclo(SGWTVVRMY)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP61 Related Classifications
HY-P10812 Related Classifications
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