CTC 96
CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research.
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- No. CAS: 149754-11-0
- Fòrmula: C20H30BrCoN6O2
- Peso molecular:525.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
CTC 96 (0-50 μg/mL, 1 h) effectively inhibits HSV-1, Varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV) infection in Vero cells[1].
CTC 96 (50 μg/mL, 1 h) specifically blocks the membrane fusion step during which the virus enters the cell and does not interfere with the attachment of HSV-1 virus particles to the surface of Vero cells[1].
CTC 96 (50 μg/mL) effectively blocks the entry of the virus, completely interrupting the release of the viral genome and the subsequent viral gene expression process in Vero cells[1].
CTC 96 (50 μg/mL, 16 h) effectively inhibits the direct transmission of the virus among the already infected Vero cells[1].
CTC-96 (0-250 μg/mL, 1 h) demonstrates virucidal activity against Ad5 in tissue culture with HeLa, A549 and SIRC cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eye adenovirus-induced corneal and conjunctival inflammation model established in New Zealand White rabbits[2]
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Dosage:25 and 50 μg/mL
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Administration:Eye drops, 6 or 9 times daily for 14-21 days
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Result:Significantly alleviated the clinical symptoms of conjunctivitis.
Significantly accelerated the clearance of the virus and shorten the course of the disease.
Chemical Information
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No. CAS 149754-11-0
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Peso molecular 525.33
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Fòrmula C20H30BrCoN6O2
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SMILES
CC1=[N]2[Co+3]3(O=C(C)[CH-]1)([N]4=C(NC=C4)C)([N]5=C(NC=C5)C)[N](CC2)=C([CH-]C(C)=O3)C.[Br-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Schwartz JA, Lium EK, Silverstein SJ. Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96. J Virol. 2001 May;75(9):4117-28. [Content Brief]
[2]. Epstein SP, et al. Efficacy of topical cobalt chelate CTC-96 against adenovirus in a cell culture model and against adenovirus keratoconjunctivitis in a rabbit model. BMC Ophthalmol. 2006 Jun 5;6:22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CTC 96 Related Classifications
HY-107009 Related Classifications
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