cTMTP1
cTMTP1 (Cyclic TMTP1) is the cyclic form of TMTP1 (HY-P11815). TMTP1 is a tumor-targeting peptide that selectively targets highly metastatic tumor cells. The cTMTP1-based [68Ga]Ga-DOTA-cTMTP1 probe is used for visualization of hepatocellular carcinoma. cTMTP1 can form a 68Ga-DOTA radiotracer that accumulates in highly metastatic cervical cancer cells and is used for microPET tumor visualization. cTMTP1 is applicable to research related to hepatocellular carcinoma and cervical cancer.
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- Fòrmula: C35H60N14O12S2
- Peso molecular:933.07
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Actividad biológica
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RDC Peptide |
cTMTP1-based radiotracer 68Ga-DOTA-TMTP1 (~18.5 KBq/well; 15-120 min; 10 μg cold cyclic TMTP1 pre-incubated for 15 min followed by 60-120 min incubation) exhibits specific, high uptake and retention in highly metastatic HeLa cervical cancer cells compared to low metastatic C-33A cells and normal End1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[68Ga]Ga-DOTA-cTMTP1 (i.v.; single dose) maintains high tumor-to-liver ratios (ranging from 2.20 to 2.55) and enables sensitive detection of small HCC lesions in transgenic c-Myc liver tumor mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (male, 5−6 weeks old, ~20 g, subcutaneous xenograft via right forelimb axillary injection of 2×106 SMMC-7721 cells)[1]
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Dosage:5.2 MBq
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Administration:i.v.; single dose
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Result:Reached tumor uptake of 1.3 %ID/g at 15 min, 1.09 %ID/g at 30 min, and 0.74 %ID/g at 150 min postinjection.
Achieved tumor-to-liver ratios of 2.65 at 30 min, 2.37 at 60 min, 2.14 at 120 min, and 2.69 at 150 min postinjection.
Reached tumor-to-muscle ratio of 11.17 at 150 min postinjection.
Exhibited blood clearance of 1.11 %ID/g at 30 min, 0.48 %ID/g at 60 min, and 0.22 %ID/g at 120 min postinjection.
Reduced tumor uptake to 0.36 %ID/g at 30 min and 0.32 %ID/g at 60 min postinjection upon coinjection of excess linear TMTP1 (p < 0.01).
Chemical Information
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Peso molecular 933.07
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Fòrmula C35H60N14O12S2
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Synonyms
Cyclic TMTP1
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Sequence
cyclo(Cys-Gly-Asn-Val-Val-Arg-Gln-Gly-Cys) (Disulfide bridge: Cys1-Cys9)
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Sequence Shortening
cyclo(CGNVVRQGC) (Disulfide bridge: Cys1-Cys9)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Meng Z, et al. Development of a Cyclic TMTP1-Based PET Probe for Visualization of Hepatocellular Carcinoma. ACS medicinal chemistry letters. 2025 Apr 10;16(4):617-624. [Content Brief]
[2]. Chen X, et al. Ga-labeled TMTP1 radiotracer for PET imaging of cervical cancer. American journal of nuclear medicine and molecular imaging. 2024;14(2):110-121. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cTMTP1 Related Classifications
HY-P11814 Related Classifications
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- cTMTP1
- Cyclic TMTP1
- cTMTP 1
- cTMTP-1
- Cyclic TMTP 1
- Cyclic TMTP-1
- Radionuclide-Drug Conjugates (RDCs)
- Drug Derivative
- cervical cancer
- HCC mouse models
- HeLa cervical cancer cells
- C-33A cells
- hepatocellular carcinoma
- End1 cells
- transgenic c-Myc liver tumor mice
- highly metastatic tumor cells
- XPNPEP2
- subcutaneous HCC xenograft mice
- Inhibitor
- inhibitor
- inhibit