Dalbergin
Based on 1 Customer Validation
Dalbergin is a composition of the extract from the Dalbergia Sissoo Linn. knot wood. Dalbergin demonstrats notable antioxidant ability.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.74%
- No. CAS: 482-83-7
- Fòrmula: C16H12O4
- Peso molecular:268.26
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μg/mL
Compound: 3
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 21784631] |
| Calvarial osteoblast | EC50 |
1.015 nM
Compound: 3
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Osteogenic activity in rat calvarial osteoblast cells assessed as induction of cell differentiation by measuring alkaline phosphatase activity using pNPP as substrate by calorimetric analysis
Osteogenic activity in rat calvarial osteoblast cells assessed as induction of cell differentiation by measuring alkaline phosphatase activity using pNPP as substrate by calorimetric analysis
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[PMID: 24803361] |
| DU-145 | IC50 |
>10 μg/mL
Compound: 3
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Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
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[PMID: 21784631] |
| KB | IC50 |
>10 μg/mL
Compound: 3
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 21784631] |
| Species | Dose | Route | Tmax | Cmax | AUC | Vz | CL | MRT |
|---|---|---|---|---|---|---|---|---|
| Rat[2] | 1.0 mg/kg | p.o. | 1.0 h | 238.49 ng/mL | 1271.39 ng·h/mL | 9458.31 mL/kg | 710.09 mL/h/kg | 8.52 h |
Chemical Information
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No. CAS 482-83-7
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Appearance Solid
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Peso molecular 268.26
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Fòrmula C16H12O4
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Color Light yellow to yellow
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SMILES
O=C1C=C(C2=CC=CC=C2)C3=CC(O)=C(OC)C=C3O1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
DMSO : 100 mg/mL (372.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7277 mL | 18.6386 mL | 37.2773 mL | 93.1932 mL |
| 5 mM | 0.7455 mL | 3.7277 mL | 7.4555 mL | 18.6386 mL | |
| 10 mM | 0.3728 mL | 1.8639 mL | 3.7277 mL | 9.3193 mL | |
| 15 mM | 0.2485 mL | 1.2426 mL | 2.4852 mL | 6.2129 mL | |
| 20 mM | 0.1864 mL | 0.9319 mL | 1.8639 mL | 4.6597 mL | |
| 25 mM | 0.1491 mL | 0.7455 mL | 1.4911 mL | 3.7277 mL | |
| 30 mM | 0.1243 mL | 0.6213 mL | 1.2426 mL | 3.1064 mL | |
| 40 mM | 0.0932 mL | 0.4660 mL | 0.9319 mL | 2.3298 mL | |
| 50 mM | 0.0746 mL | 0.3728 mL | 0.7455 mL | 1.8639 mL | |
| 60 mM | 0.0621 mL | 0.3106 mL | 0.6213 mL | 1.5532 mL | |
| 80 mM | 0.0466 mL | 0.2330 mL | 0.4660 mL | 1.1649 mL | |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9319 mL |
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