Dipeptide 2
Based on 1 Customer Validation
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC50 of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats.
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- Pureza: 98.12%
- No. CAS: 24587-37-9
- Fòrmula: C16H21N3O3
- Peso molecular:303.36
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
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eNOS |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.04 mM
Compound: 79
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Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
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[PMID: 16759105] |
| MDCK | IC50 |
0.1 mM
Compound: 79
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
Dipeptide 2 potently inhibits purified ACE with an IC50 of 10.50 ± 0.97 μM[2].
Dipeptide 2 (12.5-50 μM; 24 h) is non-toxic to HUVECs[2].
Dipeptide 2 (12.5-50 μM; 4 h) reduces intracellular calcium concentration in Ang I-induced HUVECs, promoting vascular smooth muscle relaxation[2].
Dipeptide 2 (12.5-50 μM; 4 h) promotes NO production in Ang I-induced HUVECs, with a 12.9% increase at 50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ang I-induced human umbilical vein endothelial cells (HUVECs)
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Concentration:12.5-50 μM
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Incubation Time:4 h
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Result:Significantly inhibited ET-1 protein expression and stimulated eNOS phosphorylation compared to the Ang I-only group.
Caused a 60.4% reduction in ET-1 and a 92.9% increase in p-eNOS protein expression in the 50 μM group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHRs (male, 8 weeks old, 220 ± 20 g, spontaneously hypertensive model)[2]
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Dosage:10 mg/kg; 40 mg/kg
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Administration:p.o.; once daily; 12 days
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Result:Significantly suppressed diastolic blood pressure (DBP) in SHRs between days 8 and 12, with DBP reductions ranging from 3 to 27 mmHg.
Produced a maximum DBP reduction of 27 mmHg on day 12 at 40 mg/kg.
Reduced systolic blood pressure (SBP) by 32 mmHg on day 12.
Chemical Information
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No. CAS 24587-37-9
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Appearance Solid
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Peso molecular 303.36
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Fòrmula C16H21N3O3
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Color White to off-white
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Synonyms
N-Valyltryptophan; Val-Trp
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Sequence
Val-Trp
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Sequence Shortening
VW
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 12.5 mg/mL (41.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2964 mL | 16.4821 mL | 32.9641 mL | 82.4103 mL |
| 5 mM | 0.6593 mL | 3.2964 mL | 6.5928 mL | 16.4821 mL | |
| 10 mM | 0.3296 mL | 1.6482 mL | 3.2964 mL | 8.2410 mL | |
| 15 mM | 0.2198 mL | 1.0988 mL | 2.1976 mL | 5.4940 mL | |
| 20 mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 4.1205 mL | |
| 25 mM | 0.1319 mL | 0.6593 mL | 1.3186 mL | 3.2964 mL | |
| 30 mM | 0.1099 mL | 0.5494 mL | 1.0988 mL | 2.7470 mL | |
| 40 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0603 mL |
Dipeptide 2 Related Classifications
HY-118060 Related Classifications
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