DM-NOFD
Based on 1 Customer Validation
DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.81%
- No. CAS: 865488-53-5
- Fòrmula: C13H15NO5
- Peso molecular:265.26
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Chemical Information
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No. CAS 865488-53-5
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Appearance Oil
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Peso molecular 265.26
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Fòrmula C13H15NO5
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Color Colorless to light yellow
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SMILES
COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (376.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20(18):1812-1827. [Content Brief]
[2]. Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14(43):12098-12120. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7699 mL | 18.8494 mL | 37.6989 mL | 94.2472 mL |
| 5 mM | 0.7540 mL | 3.7699 mL | 7.5398 mL | 18.8494 mL | |
| 10 mM | 0.3770 mL | 1.8849 mL | 3.7699 mL | 9.4247 mL | |
| 15 mM | 0.2513 mL | 1.2566 mL | 2.5133 mL | 6.2831 mL | |
| 20 mM | 0.1885 mL | 0.9425 mL | 1.8849 mL | 4.7124 mL | |
| 25 mM | 0.1508 mL | 0.7540 mL | 1.5080 mL | 3.7699 mL | |
| 30 mM | 0.1257 mL | 0.6283 mL | 1.2566 mL | 3.1416 mL | |
| 40 mM | 0.0942 mL | 0.4712 mL | 0.9425 mL | 2.3562 mL | |
| 50 mM | 0.0754 mL | 0.3770 mL | 0.7540 mL | 1.8849 mL | |
| 60 mM | 0.0628 mL | 0.3142 mL | 0.6283 mL | 1.5708 mL | |
| 80 mM | 0.0471 mL | 0.2356 mL | 0.4712 mL | 1.1781 mL | |
| 100 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9425 mL |
DM-NOFD Related Classifications
HY-112068 Related Classifications
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