E5700
E5700 is an orally active squalene synthase inhibitor, antimalarial agent and antifungal agent with an IC50 of 0.49 nM (without PPi) against squalene synthase from T. cruzi epimastigotes. E5700 shows antiparasitic activities against Trypanosoma cruzi. E5700 inhibits the growth and alters the lipid prolife and the ultrastructure of a multiple agent-resistant C. tropicalis strain. E5700 is a potent and selective inhibitor of the growth of Leishmania amazonensis.
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- No. CAS: 332132-39-5
- Fòrmula: C26H31N3O3
- Peso molecular:433.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Actividad biológica
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Leishmania |
Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
0.008 μM
Compound: E5700
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Antitrypanosomal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells
Antitrypanosomal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells
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[PMID: 17371809] |
Chemical Information
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No. CAS 332132-39-5
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Peso molecular 433.54
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Fòrmula C26H31N3O3
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SMILES
O[C@@]1(CN2CCC1CC2)C#CC3=CC=C(N=C3CC4=CC=CC=C4)N5C[C@H]([C@H](C5)OC)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Urbina JA, et al. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrob Agents Chemother. 2004 Jul;48(7):2379-87. [Content Brief]
[2]. Ishida K, et al. Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B. J Infect Chemother. 2011 Aug;17(4):563-70. [Content Brief]
[3]. Fernandes Rodrigues JC, et al. In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother. 2008 Nov;52(11):4098-114. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E5700 Related Classifications
HY-123746 Related Classifications
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