ELB041
ELB041 (AFS98) is a rat monoclonal anti-murine c-fms antibody (IgG2a). AFS98 inhibits M-CSF–dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. AFS98 prevents development of fatty streaks in ApoE-deficient mice. ELB041 can be used for the research of atherosclerosis.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Human
CSF1R/M-CSFR/CD115
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Apolipoprotein E (apoE)-deficient mice (female, 6 weeks of age, hybrid 129ola x C57BL/6)[1]
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Dosage:2 mg
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Administration:i.p.; alternate days; 6 weeks
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Result:Suppressed macrophage-derived foam cell accumulation in the aortic root by ~70% (total aortic lesion area: 2390 ± 204 μm² vs. PBS control: ~9000 μm²). Had minimal effect on advanced lesion size (AFS98 group: 30728 ± 2248 μm² vs. PBS group: 31753 ± 17483 μm²). Did not reduce macrophage or vascular smooth muscle cell staining in lesions. Did not significantly reduce peripheral blood monocyte count or body weight.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Synonyms
AFS98; TG3003
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ELB041 Related Classifications
HY-P991947 Related Classifications
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- ELB041
- AFS98
- TG3003
- ELB 041
- ELB-041
- AFS 98
- AFS-98
- TG3003
- TG 3003
- TG-3003
- c-Fms
- fatty streak lesion development
- cell growth
- c-fms
- vessel wall intima
- high-fat diet
- atherosclerosis
- aortic root
- apoE-deficient mice
- advanced atherosclerotic lesion size
- M-CSF
- macrophage-derived foam cells
- monocyte/macrophage
- early atherosclerotic fatty streak formation
- M-CSF-dependent colony formation
- Inhibitor
- inhibitor
- inhibit