Elemicin-d3
Based on 1 Customer Validation
Elemicin-d3 is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.53%
- No. CAS: 3028869-78-2
- Fòrmula: C12H13D3O3
- Peso molecular:211.27
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Almacenamiento:
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Elemicin (62.5, 125, 250, 500, 1000 μM) has an IC50 value of 910 μM in HepG2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 3028869-78-2
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Unlabeled Cas 487-11-6
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Appearance Liquid
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Peso molecular 211.27
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Fòrmula C12H13D3O3
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Color Colorless to light yellow
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SMILES
C=CCC1=CC(OC)=C(OC([2H])([2H])[2H])C(OC)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
Solvente y solubilidad
DMSO : 100 mg/mL (473.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under argon). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under argon). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (23.67 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (23.67 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Yi-Kun Wang, et al. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. J Agric Food Chem. 2019 Jul 24;67(29):8243-8252. [Content Brief]
[3]. Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10. [Content Brief]
[4]. Xiao-Nan Yang, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Oct 21;32(10):1965-1976. [Content Brief]
[5]. Ayodeji Oluwabunmi Oriola, et al. Essential Oils and Their Compounds as Potential Anti-Influenza Agents. Molecules. 2022 Nov 12;27(22):7797. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under argon). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7333 mL | 23.6664 mL | 47.3328 mL | 118.3320 mL |
| 5 mM | 0.9467 mL | 4.7333 mL | 9.4666 mL | 23.6664 mL | |
| 10 mM | 0.4733 mL | 2.3666 mL | 4.7333 mL | 11.8332 mL | |
| 15 mM | 0.3156 mL | 1.5778 mL | 3.1555 mL | 7.8888 mL | |
| 20 mM | 0.2367 mL | 1.1833 mL | 2.3666 mL | 5.9166 mL | |
| 25 mM | 0.1893 mL | 0.9467 mL | 1.8933 mL | 4.7333 mL | |
| 30 mM | 0.1578 mL | 0.7889 mL | 1.5778 mL | 3.9444 mL | |
| 40 mM | 0.1183 mL | 0.5917 mL | 1.1833 mL | 2.9583 mL | |
| 50 mM | 0.0947 mL | 0.4733 mL | 0.9467 mL | 2.3666 mL | |
| 60 mM | 0.0789 mL | 0.3944 mL | 0.7889 mL | 1.9722 mL | |
| 80 mM | 0.0592 mL | 0.2958 mL | 0.5917 mL | 1.4791 mL | |
| 100 mM | 0.0473 mL | 0.2367 mL | 0.4733 mL | 1.1833 mL |
Elemicin-d3 Related Classifications
HY-N6807S Related Classifications
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