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Referencia número: HY-16740

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Eprociclovir

(Synonyms: A-5021)

Eprociclovir is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir can be used in studies interfered with by sensitive viruses.

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No. CAS: 145512-85-2
Fòrmula: C₁₁H₁₅N₅O₃
Peso molecular:265.27

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Eprociclovir Chemical Structure

No. CAS: 145512-85-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target

DNA Polymerase

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>100 μg/mL Compound: 3a	Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells	[PMID: 9548818]
HEL	IC₅₀	0.67 μg/mL Compound: 1	Tested for inhibitory activity against Varicella zoster virus(VZV) by plaque reduction assay using HEL cells Tested for inhibitory activity against Varicella zoster virus(VZV) by plaque reduction assay using HEL cells	[PMID: 10649983]
HEL	IC₅₀	0.67 μg/mL Compound: 1	Tested for Antiherpetic activity against VZV from Kawaguchi strain in HEL cell lines. Tested for Antiherpetic activity against VZV from Kawaguchi strain in HEL cell lines.	[PMID: 10649983]
HFF	IC₅₀	0.2 μg/mL Compound: 3a	Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells	[PMID: 9548818]
MRC5	IC₅₀	0.0093 μg/mL Compound: 1	Tested for Antiherpetic activity against HSV-1 from Tomioka strain in MRC-5 cell lines. Tested for Antiherpetic activity against HSV-1 from Tomioka strain in MRC-5 cell lines.	[PMID: 10649983]
MRC5	IC₅₀	0.12 μg/mL Compound: 1	Tested for Antiherpetic activity against HSV-2 from 186 strain in MRC-5 cell lines. Tested for Antiherpetic activity against HSV-2 from 186 strain in MRC-5 cell lines.	[PMID: 10649983]
MRC5	IC₅₀	0.21 μg/mL Compound: 1	Tested for Antiherpetic activity against VZV from clinical isolates of MRC-5 cell lines.(average of six isolates) Tested for Antiherpetic activity against VZV from clinical isolates of MRC-5 cell lines.(average of six isolates)	[PMID: 10649983]
Vero	CC₅₀	240 μg/mL Compound: 1	Tested for cytotoxicity in vero cells, activity is expressed as CC50. Tested for cytotoxicity in vero cells, activity is expressed as CC50.	[PMID: 10649983]
Vero	CC₅₀	240 μg/mL Compound: 3a	Cytotoxic concentration to uninfected vero cells Cytotoxic concentration to uninfected vero cells	[PMID: 9548818]
Vero	IC₅₀	0.02 μg/mL Compound: 3a	Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells	[PMID: 9548818]

Chemical Information

No. CAS 145512-85-2
Peso molecular 265.27
Fòrmula C₁₁H₁₅N₅O₃
SMILES

OC[C@@]1([C@@H](C1)CO)CN2C3=C(C(N=C(N3)N)=O)N=C2
Synonyms

A-5021
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gandar F, et al. In vitro and in vivo assessment of eprociclovir as antiviral treatment against testudinid herpesvirus 3 in Hermann's tortoise (Testudo hermanni)[J]. Research in veterinary science, 2019, 124: 20-23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Eprociclovir

Ver todos los productos específicos de isoformas DNA/RNA Synthesis

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Eprociclovir Related Classifications

HY-16740 Related Classifications