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Referencia número: HY-184083

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Fenharmane

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle.

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No. CAS: 3851-30-7
Fòrmula: C₁₈H₁₈N₂
Peso molecular:262.35

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fenharmane Chemical Structure

No. CAS: 3851-30-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle^[1].

IC₅₀ & Target

^[1]

5HT2B

Ver todos los productos específicos de isoformas 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	27.4 μM Compound: 66	Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay	[PMID: 34479038]

In Vitro

Fenharmane (compound19) exhibits antagonistic activity against 5-HT-induced contractile responses in isolated fundus smooth muscle tissues of rats, with a negative logarithm of the apparent dissociation constant (-log K_B) of 7.61^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3851-30-7
Peso molecular 262.35
Fòrmula C₁₈H₁₈N₂
SMILES

C1(CC2NCCC3=C2NC4=C3C=CC=C4)=CC=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Audia JE, et al. Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J Med Chem. 1996 Jul 5;39(14):2773-80. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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