Fluoflavine
Based on 1 Customer Validation
Fluoflavine (ML-090) is a selective NOX1 inhibitor and reactive oxygen species inhibitor. Fluoflavine reduces reactive oxygen species production, NOX1-mediated downstream signaling events, and oxygen-glucose deprivation-induced retinal ganglion cell death. Fluoflavine inhibits NADPH oxidase activity and pathological retinal neovascularization induced by oxygen-induced retinopathy in the retinas of ischemic mice. Fluoflavine can be used in studies related to retinal ischemia-reperfusion injury and proliferative retinopathy.
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- Pureza: 98.47%
- No. CAS: 531-46-4
- Fòrmula: C14H10N4
- Peso molecular:234.26
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
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NOX1 |
Fluoflavine (ML-090) (0.09 μM; during OGD and 2 hours of reoxygenation) significantly reduces OGD-induced superoxide production in primary RGCs, with efficacy comparable to a nonselective NAD(P)H oxidase inhibitor[1].
Fluoflavine (0.09 μM; during 4 hours of OGD and 24 hours of reoxygenation) potently protects primary from OGD-induced apoptotic and necrotic death, with efficacy comparable to nonselective NAD(P)H oxidase inhibitors[1].
Fluoflavine (10 μM; 30 min preincubation, 2 h IL-33 treatment) attenuates IL-33-induced barrier disruption in HRMVECs, as demonstrated by reduced FITC-dextran flux[2].
Fluoflavine (10 μM; 30 min preincubation, 30 min IL-33 treatment) reduces IL-33-induced ZO-1 serine/threonine phosphorylation in HRMVECs[2].
Fluoflavine (10 μM; 30 min preincubation, 30 min IL-33 treatment) attenuates IL-33-induced PKCδ phosphorylation in HRMVECs[2].
Fluoflavine (10 μM; 30 min preincubation, 2 h IL-33 treatment) reverses IL-33-induced tight junction disruption in HRMVECs, as shown by restored ZO-1 localization at cell junctions[2].
Fluoflavine (10 μM; 30 min preincubation, 24 h IL-33 treatment) reduces IL-33-induced proliferation of HRMVECs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human retinal microvascular endothelial cells (HRMVECs)
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Concentration:10 μM
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Incubation Time:30 min (preincubation); 30 min (IL-33 treatment)
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Result:Attenuated IL-33-induced ZO-1 serine/threonine phosphorylation in HRMVECs.\nEffectively reduced IL-33-induced PKCd serine phosphorylation (at Ser643/676) in HRMVECs.
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Cell Line:human retinal microvascular endothelial cells (HRMVECs)
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Concentration:10 μM
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Incubation Time:30 min (preincubation); 2 h (IL-33 treatment)
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Result:Restored IL-33-induced tight junction breakdown, as evidenced by increased ZO-1 fluorescence intensity at cell junctions compared to IL-33-only treated cells.
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Cell Line:human retinal microvascular endothelial cells (HRMVECs)
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Concentration:10 μM
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Incubation Time:30 min (preincubation); 24 h (IL-33 treatment)
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Result:Inhibited IL-33-induced HRMVEC proliferation, as measured by reduced absorbance in the MTT assay.
Chemical Information
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No. CAS 531-46-4
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Appearance Solid
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Peso molecular 234.26
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Fòrmula C14H10N4
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Color Light yellow to yellow
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SMILES
C1(N2)=NC3=C(C=CC=C3)NC1=NC4=C2C=CC=C4
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Synonyms
ML-090
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dvoriantchikova G, et al. Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia. Invest Ophthalmol Vis Sci. 2012;53(6):2823-2830. Published 2012 May 14. [Content Brief]
[2]. Kaur G, et al. NADPH oxidase 1-PKCδ-dependent ZO-1 phosphorylation mediates IL-33-induced inner blood-retinal barrier disruption in proliferative retinopathies. Am J Physiol Cell Physiol. 2025;329(5):C1577-C1592. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fluoflavine Related Classifications
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