GB-1a
GB-1a (Biflavanone GB-1a) is a biflavanone HIV-1 reverse transcriptase inhibitor (IC50=236 μM), with an EC50 of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ.
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- No. CAS: 19360-72-6
- Fòrmula: C30H22O10
- Peso molecular:542.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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HIV-1 138 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| PBMC | IC50 |
88 μM
Compound: 11, GB-1a
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Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
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[PMID: 9322359] |
Chemical Information
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No. CAS 19360-72-6
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Peso molecular 542.49
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Fòrmula C30H22O10
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SMILES
O=C1[C@@](C2=C3C(C(C[C@](C4=CC=C(C=C4)O)([H])O3)=O)=C(C=C2O)O)([H])[C@](C5=CC=C(C=C5)O)([H])OC6=CC(O)=CC(O)=C61
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Synonyms
Biflavanone GB-1a
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GB-1a Related Classifications
HY-136972A Related Classifications
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