HMRef-αMan
HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma.
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- No. CAS: 2484831-02-7
- Fòrmula: C28H26F3NO8
- Peso molecular:561.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
HMRef-αMan (10 μM; 1 h) visualizes α-mannosidase activity in diverse live cultured human cancer cell lines[1].
HMRef-αMan (50 μM; 1-30 min) selectively and time-dependently activates fluorescence in surgically resected human IDC and DCIS tissues, enabling breast cancer detection with 90% sensitivity and 100% specificity[1].
HMRef-αMan (50 μM; 5-30 min) rapidly visualizes (within 15 min) tiny, pathologically confirmed human IDC and DCIS lesions in surgically resected specimens, with fluorescence activation limited to cancerous tissue regions[1].
HMRef-αMan (50 μM; 5-30 min) activates fluorescence in surgically resected human benign breast lesions (FA, PT, ICP, IDP), enabling discrimination from normal tissue with 100% sensitivity and 100% specificity for FA[1].
HMRef-αMan (50 μM; 15 min), when combined with a red-emitting γ-glutamyltranspeptidase probe, enables optical discrimination of surgically resected human normal breast tissue, IDC/DCIS, and FA after 15 min of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2484831-02-7
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Peso molecular 561.50
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Fòrmula C28H26F3NO8
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SMILES
OC[C@H]1O[C@@H]([C@H]([C@H]([C@@H]1O)O)O)OC2=CC=C3C(OC4=CC(NCC(F)(F)F)=CC=C4C35OCC6=C5C=CC=C6)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HMRef-αMan Related Classifications
HY-D3187 Related Classifications
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