HO 221
HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia.
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- No. CAS: 105128-93-6
- Fòrmula: C18H11BrClN5O5
- Peso molecular:492.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
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DNA Polymerase |
Chemical Information
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No. CAS 105128-93-6
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Peso molecular 492.67
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Fòrmula C18H11BrClN5O5
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SMILES
ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Nakajima T, et al. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28(5):351-6. [Content Brief]
[2]. Nakajima T, et al. Mechanism of tumor cell killing by HO-221, a novel antitumor compound. Cancer Chemother Pharmacol. 1990;27(3):199-204. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HO 221 Related Classifications
HY-106787 Related Classifications
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