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Referencia número: HY-184157

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IB15C

IB15C is an ILT3 (LILRB4) inhibitor with a human K_d of 0.92 μM. IB15C binds to a specific ILT3 pocket, disrupts ApoE interaction, and interferes with downstream inhibitory signaling pathways. IB15C reduces SHP1 and SHP2 phosphorylation, suppresses pro-inflammatory cytokine secretion, enhances amyloid uptake, and attenuates NF-κB activation. IB15C can be used for the research of alzheimer's disease.

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Fòrmula: C₂₁H₂₅N₃O₄
Peso molecular:383.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

IB15C Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

LILRB

0.92 μM (Kd)

Ver todos los productos específicos de isoformas Human leukocyte immunoglobulin (Ig)-like receptors (LILR) :

LILRB

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In Vitro

IB15C binds to recombinant human ILT3 extracellular domain with submicromolar affinity, showing an apparent K_d of 0.92 μM^[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in an ELISA-based assay with an IC₅₀ of 0.48 μM^[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in a BLI-based real-time assay with an IC₅₀ of 0.64 μM^[1].
IB15C (1-10 μM) reverses ILT3-dependent inhibitory signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia under Aβ₄₂- and ApoE-driven conditions, with no detectable cytotoxicity at concentrations up to 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 383.44
Fòrmula C₂₁H₂₅N₃O₄
SMILES

COC1=C(OC)C=CC(C(C)CNC(C2=CC(C(C(C)C)=NO3)=C3N=C2)=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Abdel-Rahman SA, et al. High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimers Disease. bioRxiv. 2026 May 21.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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IB15C

Ver todos los productos específicos de isoformas Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Ver todos los productos específicos de isoformas NF-κB

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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Help & FAQs

IB15C Related Classifications

HY-184157 Related Classifications