JG-2016
Based on 2 publication(s) in Google Scholar
JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1) with an IC50 of 14.8 μM. JG-2016 can inhibit the growth of multiple tumor cells and has anti-tumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.44%
- No. CAS: 2887480-87-5
- Fòrmula: C18H21ClN4O3
- Peso molecular:376.84
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Epigenetics Compound Library
HY-L005
-
Histone Modification Research Compound Library
HY-L024
-
Anti-Cancer Compound Library
HY-L025
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) JG-2016
More
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCC1806 | EC50 |
10.4 μM
Compound: 24a; JG-2016
|
Cytotoxicity against human HCC1806 cells assessed as inhibition of cell growth by resazurin dye based fluorescence analysis
Cytotoxicity against human HCC1806 cells assessed as inhibition of cell growth by resazurin dye based fluorescence analysis
|
[PMID: 37027002] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 2887480-87-5
-
Appearance Solid
-
Peso molecular 376.84
-
Fòrmula C18H21ClN4O3
-
Color Light yellow to yellow
-
SMILES
O=C(N1)N=C2N(CCOCC(C)C)C3=CC(CC)=C(Cl)C=C3N=C2C1=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Acta Pharm Sin B
Succinylation of tumor suppressor PPP2R1A K541 by HAT1 converses the role in modulation of gluconeogenesis/lipogenesis remodeling to display oncogene function. [Abstract]2025 Oct;15(10):5294-5311. PMID: 41132830 -
Oncol Lett
Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle. [Abstract]2025 Sep 22;30(6):539. PMID: 41050772
Solvente y solubilidad
DMSO : 100 mg/mL (265.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6536 mL | 13.2682 mL | 26.5365 mL | 66.3412 mL |
| 5 mM | 0.5307 mL | 2.6536 mL | 5.3073 mL | 13.2682 mL | |
| 10 mM | 0.2654 mL | 1.3268 mL | 2.6536 mL | 6.6341 mL | |
| 15 mM | 0.1769 mL | 0.8845 mL | 1.7691 mL | 4.4227 mL | |
| 20 mM | 0.1327 mL | 0.6634 mL | 1.3268 mL | 3.3171 mL | |
| 25 mM | 0.1061 mL | 0.5307 mL | 1.0615 mL | 2.6536 mL | |
| 30 mM | 0.0885 mL | 0.4423 mL | 0.8845 mL | 2.2114 mL | |
| 40 mM | 0.0663 mL | 0.3317 mL | 0.6634 mL | 1.6585 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5307 mL | 1.3268 mL | |
| 60 mM | 0.0442 mL | 0.2211 mL | 0.4423 mL | 1.1057 mL | |
| 80 mM | 0.0332 mL | 0.1659 mL | 0.3317 mL | 0.8293 mL | |
| 100 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6634 mL |
JG-2016 Related Classifications
HY-154944 Related Classifications
Powered by Bioz