L-NIO
Based on 2 publication(s) in Google Scholar
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO induces a consistentfocal ischemic infarctin rats.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 36889-13-1
- Fòrmula: C7H15N3O2
- Peso molecular:173.21
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-NIO
More
Actividad biológica
Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW | IC50 |
9 μM
Compound: L-NIO
|
Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
|
[PMID: 9873655] |
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 36889-13-1
-
Peso molecular 173.21
-
Fòrmula C7H15N3O2
-
SMILES
CC(NCCC[C@@H](C(O)=O)N)=N
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Cell Mol Gastroenterol Hepatol
2021;11(3):683-696. PMID: 33075564 -
Eur J Pharmacol
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway. [Abstract]2026 Apr 24:178896. PMID: 42035941
Pureza y Documentación
Referencias
[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz