LC-U7-44
LC-U7-44 is a potent USP7 inhibitor with an IC50 of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer.
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- Fòrmula: C28H32N6O3
- Peso molecular:500.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
USP7 0.96 μM (IC50) |
In Vitro
LC-U7-44 (10 μM; 20-30 min) potently inhibits purified USP7 protein with an IC50 of 0.96 μM in a fluorescence polarization binding assay[1].
LC-U7-44 potently inhibits the enzymatic activity of purified USP7 protein with an IC50 of 0.46 μM in a Ub-Rho assay[1].
LC-U7-44 (0.01-100 μM; 6 days) potently inhibits the proliferation of LNCaP cells with an IC50 of 1.83 μM following 6 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:lymph node carcinoma of the prostate (LNCaP) cells
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Concentration:0.01-100 μM
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Incubation Time:6 days
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Result:Suppressed LNCaP cell proliferation with an IC50 of 1.83 μM.
Chemical Information
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Peso molecular 500.59
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Fòrmula C28H32N6O3
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SMILES
CN1N=C2C(N=CN(CC3(O)CCN(C(CCC4=CC=CC=C4)=O)CC3)C2=O)=C1C5=CC=C(CN)C=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LC-U7-44 Related Classifications
HY-183282 Related Classifications
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