MC4171
Based on 2 publication(s) in Google Scholar
MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.37%
- No. CAS: 3034769-78-0
- Fòrmula: C21H15N3O3
- Peso molecular:357.36
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC4171
More
Actividad biológica
Descripciòn
IC50 & Target
KAT8[1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
33 μM
Compound: 34; MC4171
|
Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37155735] |
| HCT-116 | IC50 |
46.6 μM
Compound: 34; MC4171
|
Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37155735] |
| HT-29 | IC50 |
54 μM
Compound: 34; MC4171
|
Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37155735] |
| NCI-H1299 | IC50 |
41.6 μM
Compound: 34; MC4171
|
Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37155735] |
| U-937 | IC50 |
51.7 μM
Compound: 34; MC4171
|
Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37155735] |
Chemical Information
-
No. CAS 3034769-78-0
-
Appearance Solid
-
Peso molecular 357.36
-
Fòrmula C21H15N3O3
-
Color Brown to orange
-
SMILES
O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3)/C(C2=O)=C/C4=CC=CN4)C=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Int J Biol Macromol
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance. [Abstract]2025 Aug 5;322(Pt 1):146571. PMID: 40769364 -
Commun Biol
MOF-mediated H4K16ac is critical for blastocyst formation in sheep by shaping promoter accessibility and transcription. [Abstract]2026 Mar 17;9(1):609. PMID: 41844839
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (69.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureza y Documentación
-
Ficha de datos (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7983 mL | 13.9915 mL | 27.9830 mL | 69.9575 mL |
| 5 mM | 0.5597 mL | 2.7983 mL | 5.5966 mL | 13.9915 mL | |
| 10 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL | 6.9957 mL | |
| 15 mM | 0.1866 mL | 0.9328 mL | 1.8655 mL | 4.6638 mL | |
| 20 mM | 0.1399 mL | 0.6996 mL | 1.3991 mL | 3.4979 mL | |
| 25 mM | 0.1119 mL | 0.5597 mL | 1.1193 mL | 2.7983 mL | |
| 30 mM | 0.0933 mL | 0.4664 mL | 0.9328 mL | 2.3319 mL | |
| 40 mM | 0.0700 mL | 0.3498 mL | 0.6996 mL | 1.7489 mL | |
| 50 mM | 0.0560 mL | 0.2798 mL | 0.5597 mL | 1.3991 mL | |
| 60 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1660 mL |
MC4171 Related Classifications
HY-153604 Related Classifications
Powered by Bioz