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Referencia número: HY-120576

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ML169

(Synonyms: VU0405652)

ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M₁ mAChR, with an EC₅₀ of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.

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No. CAS: 1222878-02-5
Fòrmula: C₂₁H₁₇BrFN₃O₄S
Peso molecular:506.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

ML169 Chemical Structure

No. CAS: 1222878-02-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

IC₅₀ & Target

EC₅₀: 1.38 µM (M1 mAChR)^[1]

Ver todos los productos específicos de isoformas mAChR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1.38 μM Compound: 15j, VU0405652, ML169	Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay	[PMID: 21194936]

In Vitro

ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M₁–M₅^[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway^[1].
ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML169 (VU0405652) (10 mg/kg; i.p.) affords a brain_AUC/plasma_AUC of 0.32 at 1 h in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1222878-02-5
Peso molecular 506.34
Fòrmula C₂₁H₁₇BrFN₃O₄S
SMILES

O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
Synonyms

VU0405652
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Reid PR, et al. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorg Med Chem Lett. 2011 May 1;21(9):2697-701. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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ML169

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas mAChR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ML169 Related Classifications

HY-120576 Related Classifications