MS-L6
Based on 1 publication(s) in Google Scholar
MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma.
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- Pureza: 99.95%
- No. CAS: 63498-32-8
- Fòrmula: C20H28Br2N4S2
- Peso molecular:548.40
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) MS-L6
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Actividad biológica
MS-L6 (10 µM; 48 h) reduces viability in a panel of human hematological cancer cell lines, with varying potency across leukemia, B lymphoma, and T lymphoma subtypes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Panel of human hematological cancer cell lines (including leukemia, B lymphoma, and T lymphoma cell lines)
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Concentration:10 µM
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Incubation Time:48 h
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Result:Reduced viable cell counts across the panel of hematological cancer cell lines to varying degrees: in leukemia lines (e.g., HL60, U937, THP1, K562), viable cell percentages ranged from 55-85%.
Reduced viable cell percentages in B lymphoma lines (e.g., SUDHL6, OCYL3, PFEIFER, NALM6, DAUDI, BJAB, VL51, SSK41) to a range of 40-110%.
Reduced viable cell percentages in T lymphoma lines (e.g., JURKAT, OCY13.2, DERL2, MONT1, SRY86, HUT78, MYLA, K299) to a range of 70-95%.
MS-L6 (50 mg/kg; i.p.; five times per week) blocks SUDHL4 non-Hodgkin B-cell lymphoma xenograft tumor growth in SCID mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice[1]
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Dosage:50 mg/kg
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Administration:i.p.; five times per week
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Result:Induced a significant reduction in RL tumor volume compared to vehicle control, with median tumor volumes on day 28 post-cell graft being notably lower in the MS-L6 group.\nBlocked SUDHL4 tumor growth, with median tumor volumes remaining suppressed and significantly lower than vehicle control by study endpoint.
Chemical Information
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No. CAS 63498-32-8
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Appearance Solid
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Peso molecular 548.40
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Fòrmula C20H28Br2N4S2
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Color White to off-white
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SMILES
N=C(NC1=CC=CC=C1)SCCCCCCSC(NC2=CC=CC=C2)=N.Br.Br
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 125 mg/mL (227.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 4 mg/mL (7.29 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8235 mL | 9.1174 mL | 18.2349 mL | 45.5872 mL |
| 5 mM | 0.3647 mL | 1.8235 mL | 3.6470 mL | 9.1174 mL | |
| DMSO | 10 mM | 0.1823 mL | 0.9117 mL | 1.8235 mL | 4.5587 mL |
| 15 mM | 0.1216 mL | 0.6078 mL | 1.2157 mL | 3.0391 mL | |
| 20 mM | 0.0912 mL | 0.4559 mL | 0.9117 mL | 2.2794 mL | |
| 25 mM | 0.0729 mL | 0.3647 mL | 0.7294 mL | 1.8235 mL | |
| 30 mM | 0.0608 mL | 0.3039 mL | 0.6078 mL | 1.5196 mL | |
| 40 mM | 0.0456 mL | 0.2279 mL | 0.4559 mL | 1.1397 mL | |
| 50 mM | 0.0365 mL | 0.1823 mL | 0.3647 mL | 0.9117 mL | |
| 60 mM | 0.0304 mL | 0.1520 mL | 0.3039 mL | 0.7598 mL | |
| 80 mM | 0.0228 mL | 0.1140 mL | 0.2279 mL | 0.5698 mL | |
| 100 mM | 0.0182 mL | 0.0912 mL | 0.1823 mL | 0.4559 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MS-L6 Related Classifications
HY-158421 Related Classifications
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- MS-L6
- 63498-32-8
- Oxidative Phosphorylation
- Mitochondrial Metabolism
- ATP Synthase
- Reactive Oxygen Species (ROS)
- Parasite
- murine lymphoma xenograft models
- ubiquinone site
- mitochondrial respiratory complex I
- T-cell lymphoma
- non-Hodgkin B-cell lymphoma
- human hematological cancer cell lines
- ROS
- pediatric sarcoma
- human PBMCs
- B-cell lymphoma
- Inhibitor
- inhibitor
- inhibit