MY10
Based on 1 Customer Validation
MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.86%
- No. CAS: 2204270-73-3
- Fòrmula: C15H10F6OS2
- Peso molecular:384.36
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
receptor protein tyrosine phosphatase (RPTPβ/ζ)[1]
In Vitro
MY10 (0.1-10 μM, 24 h) decreases the viability of both SH-SY5Y neuroblastoma cells and BV2 microglial cells[2].
MY10 (10 μM) increases proliferation, migration, and tube formation of Ptprz1+/+ pulmonary microvascular endothelial cells (LMVECs)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats (male, 375-440 g) in alcohol operant self- administration paradigm and Drinking In the Dark - Multiple Scheduled Access (DID-MSA) paradigm[5]
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Dosage:20, 60, 100 mg/kg (in 10% dehydrated ethanol, 20% polysorbate 80, and 70% PEG 300 vehicle)
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Administration:Administered by oral gavage, once 1 hour before the voluntary alcohol consumption, for 3 days.
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Result:Caused a significant 26.1% reduction in alcohol consumption at 100 mg/kg (in the alcohol operant self-administration paradigm).
Caused a 28.1% decrease in cumulative alcohol intake (in the DID-MSA paradigm).
Decreased the alcohol preference.
Had no effect on saccharin intake.
Prevented the alcohol-induced down-regulation of Prprzl and Alk gene expression.
Chemical Information
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No. CAS 2204270-73-3
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Appearance Solid
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Peso molecular 384.36
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Fòrmula C15H10F6OS2
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Color White to off-white
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SMILES
FC(SC1=CC=C(C=C1)COC2=CC=C(SC(F)(F)F)C=C2)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (130.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. [Content Brief]
[2]. Del Campo M, et al. Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease. Int J Mol Sci. 2021 Jun 22;22(13):6646. [Content Brief]
[3]. Fernández-Calle R, et al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. [Content Brief]
[4]. Kastana P, et al. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. Int J Cancer. 2023 Sep 1;153(5):1051-1066. [Content Brief]
[5]. Calleja-Conde J, et al. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44(5):1037-1045. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6017 mL | 13.0086 mL | 26.0173 mL | 65.0432 mL |
| 5 mM | 0.5203 mL | 2.6017 mL | 5.2035 mL | 13.0086 mL | |
| 10 mM | 0.2602 mL | 1.3009 mL | 2.6017 mL | 6.5043 mL | |
| 15 mM | 0.1734 mL | 0.8672 mL | 1.7345 mL | 4.3362 mL | |
| 20 mM | 0.1301 mL | 0.6504 mL | 1.3009 mL | 3.2522 mL | |
| 25 mM | 0.1041 mL | 0.5203 mL | 1.0407 mL | 2.6017 mL | |
| 30 mM | 0.0867 mL | 0.4336 mL | 0.8672 mL | 2.1681 mL | |
| 40 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6261 mL | |
| 50 mM | 0.0520 mL | 0.2602 mL | 0.5203 mL | 1.3009 mL | |
| 60 mM | 0.0434 mL | 0.2168 mL | 0.4336 mL | 1.0841 mL | |
| 80 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8130 mL | |
| 100 mM | 0.0260 mL | 0.1301 mL | 0.2602 mL | 0.6504 mL |
MY10 Related Classifications
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