Ned 19
Based on 3 publication(s) in Google Scholar
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.92%
- No. CAS: 874374-25-1
- Fòrmula: C30H31FN4O3
- Peso molecular:514.59
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ned 19
MoreVer todos los productos específicos de isoformas Calcium Channel
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Actividad biológica
Descripciòn
IC50 & Target
NAADP, Ca2+[1]
In Vitro
Ned 19 (25-100 μM; 24-72 hours) reduces cell proliferation[2].
Ned 19 (25-100 μM; 24-72 hours) reduces markedly the cell number[2].
Ned 19 (25-100 μM; 24-72 hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis[2].
Ned 19 (25-100 μM; 24-72 hours) induces cell apoptosis a time-dependent manner[2].
Ned 19 (25-100 μM; 24-72 hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Reduced cell proliferation.
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Cell Line:B16 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Reduced markedly the cell number.
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Cell Line:B16 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Reduced the S phase percentage and increased of the G0/G1 phase percentage.
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Cell Line:B16 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Induced cell apoptosis a time-dependent manner.
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Cell Line:B16 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Reduced expression of N-cadherin and increased expression of E-cadherin.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male C57BL/6 mice[2]
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Dosage:5 mg/Kg
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Administration:I.p.; every second day; 4 week
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Result:Impaired severely tumor growth.
Chemical Information
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No. CAS 874374-25-1
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Appearance Solid
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Peso molecular 514.59
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Fòrmula C30H31FN4O3
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Color Off-white to light yellow
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SMILES
OC(C(C1)NC(C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4F)CC3)=C2)C5=C1C6=C(N5)C=CC=C6)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 and causes lysosome acidification and hypopigmentation. [Abstract]2023 Jan 14;14(1):226. PMID: 36641477 -
Adv Sci (Weinh)
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [Abstract]2025 Jul 25:e15313. PMID: 40709664 -
Cell Rep
Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington's disease. [Abstract]2023 Dec 26;42(12):113573. PMID: 38096054
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (242.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9433 mL | 9.7165 mL | 19.4329 mL | 48.5824 mL |
| 5 mM | 0.3887 mL | 1.9433 mL | 3.8866 mL | 9.7165 mL | |
| 10 mM | 0.1943 mL | 0.9716 mL | 1.9433 mL | 4.8582 mL | |
| 15 mM | 0.1296 mL | 0.6478 mL | 1.2955 mL | 3.2388 mL | |
| 20 mM | 0.0972 mL | 0.4858 mL | 0.9716 mL | 2.4291 mL | |
| 25 mM | 0.0777 mL | 0.3887 mL | 0.7773 mL | 1.9433 mL | |
| 30 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL | 1.6194 mL | |
| 40 mM | 0.0486 mL | 0.2429 mL | 0.4858 mL | 1.2146 mL | |
| 50 mM | 0.0389 mL | 0.1943 mL | 0.3887 mL | 0.9716 mL | |
| 60 mM | 0.0324 mL | 0.1619 mL | 0.3239 mL | 0.8097 mL | |
| 80 mM | 0.0243 mL | 0.1215 mL | 0.2429 mL | 0.6073 mL | |
| 100 mM | 0.0194 mL | 0.0972 mL | 0.1943 mL | 0.4858 mL |
Ned 19 Related Classifications
HY-103316A Related Classifications
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