NT1-O14B
Based on 2 publication(s) in Google Scholar
NT1-O14B is a tryptamine-derived lipidoid. NT1-O14B incorporates NT-lipidoid into BBB-impermeable lipid nanoparticles (LNPs), enabling the LNPs to cross the BBB. NT1-O14B enhances brain delivery via intravenous injection. NT1-O14B can be used in ischemic stroke research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.43%
- No. CAS: 2739805-64-0
- Fòrmula: C40H68N2O4S4
- Peso molecular:769.24
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NT1-O14B
More
Actividad biológica
NT1-014B 用于制备平均粒径在 140-170 nm 的 LNP3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2739805-64-0
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Appearance Viscous Liquid
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Peso molecular 769.24
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Fòrmula C40H68N2O4S4
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Color Colorless to light yellow
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SMILES
O=C(CCN(CCC(OCCSSCCCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)OCCSSCCCCCCCCCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Biomater
Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery. [Abstract]2025 Oct 11:S1742-7061(25)00762-7. PMID: 41083040 -
Mol Pharm
2026 May 4;23(5):2944-2954. PMID: 41931102
Solvente y solubilidad
DMSO : 150 mg/mL (195.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020 Jul 24;6(30):eabb4429. [Content Brief]
[2]. Jia Y, et al. Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. Adv Mater. 2025 Mar 27:e2500598. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3000 mL | 6.4999 mL | 12.9998 mL | 32.4996 mL |
| 5 mM | 0.2600 mL | 1.3000 mL | 2.6000 mL | 6.4999 mL | |
| 10 mM | 0.1300 mL | 0.6500 mL | 1.3000 mL | 3.2500 mL | |
| 15 mM | 0.0867 mL | 0.4333 mL | 0.8667 mL | 2.1666 mL | |
| 20 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6250 mL | |
| 25 mM | 0.0520 mL | 0.2600 mL | 0.5200 mL | 1.3000 mL | |
| 30 mM | 0.0433 mL | 0.2167 mL | 0.4333 mL | 1.0833 mL | |
| 40 mM | 0.0325 mL | 0.1625 mL | 0.3250 mL | 0.8125 mL | |
| 50 mM | 0.0260 mL | 0.1300 mL | 0.2600 mL | 0.6500 mL | |
| 60 mM | 0.0217 mL | 0.1083 mL | 0.2167 mL | 0.5417 mL | |
| 80 mM | 0.0162 mL | 0.0812 mL | 0.1625 mL | 0.4062 mL | |
| 100 mM | 0.0130 mL | 0.0650 mL | 0.1300 mL | 0.3250 mL |
NT1-O14B Related Classifications
HY-137500 Related Classifications
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