OMDM-2
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 3.0 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 616884-63-0
- Fòrmula: C27H45NO3
- Peso molecular:431.65
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Endogenous Metabolite
More
Actividad biológica
Ki: 3.0 μM (anandamide cellular uptake)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
23.29 μM
Compound: OMDM-2
|
Inhibition of FAAH-mediated [ethanol-amine-1-3H]AEA hydrolysis in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
Inhibition of FAAH-mediated [ethanol-amine-1-3H]AEA hydrolysis in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
|
[PMID: 24972328] |
| U-937 | IC50 |
4.12 μM
Compound: OMDM-2
|
Inhibition of [ethanol-amine-1-3H]AEA uptake in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
Inhibition of [ethanol-amine-1-3H]AEA uptake in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
|
[PMID: 24972328] |
OMDM-2 shows poor affinity for either CB1 (Ki=5.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively; OMDM-2 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50=10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 616884-63-0
-
Peso molecular 431.65
-
Fòrmula C27H45NO3
-
SMILES
CCCCCCCC/C=C\CCCCCCCC(N[C@H](CC1=CC=C(O)C=C1)CO)=O
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OMDM-2 Related Classifications
HY-103342 Related Classifications
Powered by Bioz