Parishin
Based on 4 publication(s) in Google Scholar
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.92%
- No. CAS: 62499-28-9
- Fòrmula: C45H56O25
- Peso molecular:996.91
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Parishin
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RT-PCR
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Histological Imaging/Staining
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WB
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Cell Proliferation/Viability Assay
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IF
Actividad biológica
Sir2/Uth1/TOR[1]
Parishin extends the replicative lifespan of K6001 yeast at 3, 10, and 30?μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 62499-28-9
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Appearance Solid
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Peso molecular 996.91
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Fòrmula C45H56O25
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Color Off-white to light yellow
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SMILES
O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=CC=C(COC(C(CC(OCC3=CC=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO)C=C3)=O)(O)CC(OCC5=CC=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO)C=C5)=O)=O)C=C2
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Parishin from Gastrodia elata ameliorates DSS induced colitis and anxiety-like behavior in mice by regulating intestinal barrier function and microviota-gut-brain axis. [Abstract]2025 Jun 22:145:157019. PMID: 40582206 -
J Inflamm Res
Parishin Protects Against Sepsis-Induced Intestinal Injury by Modulating the ACSL4/p-Smad3/PGC-1α Pathway: An Integrated Approach of Bioinformatics and Experimental Validation. [Abstract]2025 Oct 15:18:14283-14305. PMID: 41126972
Parishin purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Oct 15:18:14283-14305. [Abstract]
mRNA expression of ferroptosis-related genes in septic mice following Parishin (50 mg/kg, i.p.) treatment.
Parishin purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Oct 15:18:14283-14305. [Abstract]
Histological evaluation of intestinal mucosa in mice, and transmission electron microscopy (TEM) images of intestinal villi treated with Parishin (50 mg/kg, i.p.).
Parishin purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Oct 15:18:14283-14305. [Abstract]
Expression levels of ZO-1 protein in intestinal tissues treated with Parishin (20, 50 μM).
Parishin purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Oct 15:18:14283-14305. [Abstract]
Cell viability on IEC-6 cells treated with Parishin (20, 50 μM).
Parishin purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Oct 15:18:14283-14305. [Abstract]
Laser confocal microscopy analysis of IEC6 cells treated with Parishin (20, 50 μM).
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Solvente y solubilidad
DMSO : 125 mg/mL (125.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (100.31 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (6.27 mM); Clear solution
This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (6.27 mM); Clear solution
This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: 50 mg/mL (50.15 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Español - ES (393 KB)
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- Korean - KR (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.0031 mL | 5.0155 mL | 10.0310 mL | 25.0775 mL |
| 5 mM | 0.2006 mL | 1.0031 mL | 2.0062 mL | 5.0155 mL | |
| 10 mM | 0.1003 mL | 0.5015 mL | 1.0031 mL | 2.5077 mL | |
| 15 mM | 0.0669 mL | 0.3344 mL | 0.6687 mL | 1.6718 mL | |
| 20 mM | 0.0502 mL | 0.2508 mL | 0.5015 mL | 1.2539 mL | |
| 25 mM | 0.0401 mL | 0.2006 mL | 0.4012 mL | 1.0031 mL | |
| 30 mM | 0.0334 mL | 0.1672 mL | 0.3344 mL | 0.8359 mL | |
| 40 mM | 0.0251 mL | 0.1254 mL | 0.2508 mL | 0.6269 mL | |
| 50 mM | 0.0201 mL | 0.1003 mL | 0.2006 mL | 0.5015 mL | |
| 60 mM | 0.0167 mL | 0.0836 mL | 0.1672 mL | 0.4180 mL | |
| 80 mM | 0.0125 mL | 0.0627 mL | 0.1254 mL | 0.3135 mL | |
| 100 mM | 0.0100 mL | 0.0502 mL | 0.1003 mL | 0.2508 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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