Pectic acid
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Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease.
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- No. CAS: 9046-40-6
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
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Human Endogenous Metabolite |
Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells[1].
Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining[2].
Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner[2].
Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GH3/B6 cells
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Concentration:1 mg/mL
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Incubation Time:24 h
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Result:Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells.
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ulcerative colitis (UC) mice[3]
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Dosage:25, 100 mg/kg
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Administration:Oral gavage
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Result:Exhibited the longest colon, lowest DAI, and minimum histopathological score.
Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
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Animal Model:Ulcerative colitis (UC) mice[3]
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Dosage:6.25, 12.5 mg/kg
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Administration:Intravenous injection
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Result:Decreased the spleen and thymus index.
Restored the Th17/Treg balance in the spleen and lamina propria of UC mice.
Improved the gut microbiota composition.
Chemical Information
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No. CAS 9046-40-6
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Appearance Solid
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Color White to off-white
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SMILES
[Pectic acid]
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Synonyms
Methyl protopectin; Polygalacturonic acid
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
H2O : 20 mg/mL (Need ultrasonic)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72. [Content Brief]
[2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36. [Content Brief]
[3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pectic acid Related Classifications
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