Pirepemat
Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease. IRL752 is a selective enhancer of cortical dopamine, acetylcholine and norepinephrine.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Pirepemat fumarate) that retains the same biological activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1227638-29-0
- Fòrmula: C11H13F2NO
- Peso molecular:213.22
-
Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Dopamine Receptor
MoreVer todos los productos específicos de isoformas Adrenergic Receptor
More
Actividad biológica
Descripciòn
In Vitro
IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Normal rats[2].
-
Dosage:3.7-100 µmol/kg.
-
Administration:s.c., 30 min prior to testing.
-
Result:Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 1227638-29-0
-
Appearance Oil
-
Peso molecular 213.22
-
Fòrmula C11H13F2NO
-
Color Off-white to brown
-
SMILES
CO[C@]1(C(C=CC=C2F)=C2F)CCNC1
-
Synonyms
IRL752
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
-
Ficha de datos (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Systematic review of pharmacological interventions for people with Lewy body dementia
[3]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pirepemat Related Classifications
HY-137447 Related Classifications
Powered by Bioz