Placulumab
Based on 1 Customer Validation
Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 96.84%
- No. CAS: 945781-29-3
- Peso molecular:76.12 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
Isotype
[V-kappa]2-Fc
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
TNF
In Vitro
Placulumab (0.01-1000 µg/mL) has cytotoxicity to NS0 cells and peripheral blood mononuclear cells (PBMCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pharmacokinetic (PK) parameters of Placulumab in cynomolgus macaques[1]
| Route | Dose (mg/kg) | Exposure AUC0-336 h (ng.h/mL) | Maximum concentration Cmax (ng/mL) | Time of maximum concentration tmax (h) | Elimination half-life t1/2 (h) | Clearance CL (mL/hr/kg) |
| Intravenous injection (Males) | 50 | 46000000 | 1320000 | 0.167 | 104 | 0.985 |
| Intravenous injection (Females) | 50 | 43300000 | 1020000 | 0.211 | 97.4 | 1.06 |
| Route | Dose (mg/kg) | Exposure AUC0-336 h (ng.h/mL) | Dose normalize exposure AUC0-336 h (norm) | Maximum concentration Cmax (ng/mL) | Time of maximum concentration tmax (h) | Elimination half-life t1/2 (h) |
| Subcutaneous injection (Males) | 0.5 | 676000 | 1350000 | 3190 | 50.0 | 120 |
| Subcutaneous injection (Females) | 0.5 | 445000 | 890000 | 2880 | 48.0 | 108 |
| Subcutaneous injection (Males) | 5 | 3940000 | 788000 | 22700 | 40.0 | 117 |
| Subcutaneous injection (Females) | 5 | 3840000 | 767000 | 23800 | 12.0 | 109 |
| Subcutaneous injection (Males) | 50 | 41600000 | 832000 | 272000 | 40.0 | 122 |
| Subcutaneous injection (Females) | 50 | 32300000 | 646000 | 212000 | 32.0 | 107 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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[V-kappa]2-Fc
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized TNF-alpha/TNFSF2 Protein, Human, HY-P7058 can bind Placulumab. The EC50 for this effect is 10.38 ng/mL.
Chemical Information
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No. CAS 945781-29-3
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Appearance Liquid
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Peso molecular 76.12 kDa
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Color Colorless to light yellow
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SMILES
[Placulumab]
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Synonyms
ART621; CEP-37247; PN0621
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (261 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Placulumab Related Classifications
HY-P99775 Related Classifications
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