(+)-Epiloliolide
Based on 1 Customer Validation
(+)-Epiloliolide is a megastigmane that can be isolated from Annona muricata. (+)-epiloliolide increased the nuclear localization of p53. (+)-Epiloliolide has anti-inflammatory effect through upregulating phosphorylation of the PKA/CREB pathway. (+)-Epiloliolide also effectively increases the proliferation and migration of human periodontal ligament cells by downregulating NLRP3 activated by PG-LPS.
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- Pureza: 95.0%
- No. CAS: 38274-00-9
- Fòrmula: C11H16O3
- Peso molecular:196.24
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Actividad biológica
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NLRP3 |
Chemical Information
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No. CAS 38274-00-9
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Appearance Solid
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Peso molecular 196.24
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Fòrmula C11H16O3
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Color Off-white to light yellow
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SMILES
C[C@@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O
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Synonyms
Isololiolide
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Matsushige A, et al. Three new megastigmanes from the leaves of Annona muricata. J Nat Med. 2012 Apr;66(2):284-91. [Content Brief]
[2]. Chung Y, Jeong S, Lee IK, et al. Regulation of p53 Activity by (+)-Epiloliolide Isolated from Ulva lactuca. Mar Drugs. 2021;19(8):450. [Content Brief]
[3]. Kim EN, Nabende WY, Jeong H, Hahn D, Jeong GS. The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells. Mar Drugs. 2021;19(7):388. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-Epiloliolide Related Classifications
HY-N10173 Related Classifications
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