PTC258
Based on 1 Customer Validation
PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model.
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- Pureza: 99.84%
- No. CAS: 2476724-74-8
- Fòrmula: C16H18ClN3S2
- Peso molecular:351.92
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Familial Dysautonomia (FD) Mouse model[1]
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Dosage:3 mg/kg, 6 mg/kg, 12 mg/kg, 24 mg/kg
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Administration:Oral gavage; once daily for 3 month
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Result:Increased full-length ELP1 transcript in a dose-dependent manner. And also, it increased in functional ELP1 protein in the brain, trigeminal, liver, and quadricep.
Chemical Information
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No. CAS 2476724-74-8
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Appearance Solid
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Peso molecular 351.92
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Fòrmula C16H18ClN3S2
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Color White to yellow
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SMILES
CC(C1=NC(Cl)=CC(NCC2=CC=CS2)=C1S3)=C3C[C@H](C)N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (284.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8416 mL | 14.2078 mL | 28.4155 mL | 71.0389 mL |
| 5 mM | 0.5683 mL | 2.8416 mL | 5.6831 mL | 14.2078 mL | |
| 10 mM | 0.2842 mL | 1.4208 mL | 2.8416 mL | 7.1039 mL | |
| 15 mM | 0.1894 mL | 0.9472 mL | 1.8944 mL | 4.7359 mL | |
| 20 mM | 0.1421 mL | 0.7104 mL | 1.4208 mL | 3.5519 mL | |
| 25 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8416 mL | |
| 30 mM | 0.0947 mL | 0.4736 mL | 0.9472 mL | 2.3680 mL | |
| 40 mM | 0.0710 mL | 0.3552 mL | 0.7104 mL | 1.7760 mL | |
| 50 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 60 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL | 1.1840 mL | |
| 80 mM | 0.0355 mL | 0.1776 mL | 0.3552 mL | 0.8880 mL | |
| 100 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL |
PTC258 Related Classifications
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