SCH-23390
Based on 34 publication(s) in Google Scholar
SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system.
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- No. CAS: 87075-17-0
- Fòrmula: C17H18ClNO
- Peso molecular:287.78
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) SCH-23390
More- Nat Commun. 2026 Jun 16. [Abstract]
- Nat Commun. 2024 Jun 10;15(1):4947. [Abstract]
- Nat Commun. 2024 May 1;15(1):3685. [Abstract]
- Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
- Microbiome. 2020 Aug 20;8(1):120. [Abstract]
- Adv Sci (Weinh). 2025 Sep;12(33):e02276. [Abstract]
- J Neuroinflammation. 2026 Apr 23. [Abstract]
- J Hazard Mater. 2025 Sep 15:496:139466. [Abstract]
- Acta Pharmacol Sin. 2026 Apr 24. [Abstract]
- Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
- Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Abstract]
- Int J Biol Macromol. 2023 Aug 30:247:125703. [Abstract]
- Cell Rep. 2024 Sep 10;43(9):114717. [Abstract]
- Neuropsychopharmacology. 2024 Aug;49(9):1468-1480. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117576. [Abstract]
- Food Biosci. 2025 Oct.
- Eur J Pharmacol. 2024 Oct 15:981:176866. [Abstract]
- Int Immunopharmacol. 2020 Nov:88:106963. [Abstract]
- Neurochem Int. 2023 Feb:163:105479. [Abstract]
- J Psychiatry Neurosci. 2024 Feb 1;49(1):E23-E34. [Abstract]
- Brain Res Bull. 2021 Oct:175:136-149. [Abstract]
- Aquaculture. 2025 Apr 15.
- J Neurosci. 2025 Sep 3;45(36):e0382252025. [Abstract]
- Insect Biochem Mol Biol. 2025 May:180:104312. [Abstract]
- J Neurosci. 2024 Aug 21;44(34):e0740242024. [Abstract]
- Mol Brain. 2025 Jul 16;18(1):63. [Abstract]
- Viruses. 2021 Aug 3;13(8):1533. [Abstract]
- Psychopharmacology (Berl). 2022 Mar;239(3):951-964. [Abstract]
- Biochem Biophys Res Commun. 2022 Nov 12:629:183-188. [Abstract]
- Biochem Biophys Res Commun. 2022 Jan 15:588:83-89. [Abstract]
- Med Sci Monit. 2021 Oct 18;27:e933278. [Abstract]
- Neurosci Lett. 2021 Aug 24:760:136102. [Abstract]
- Behav Pharmacol. 2024 Jun 1;35(4):193-200. [Abstract]
- bioRxiv. 2024 Dec 23:2024.12.22.629999. [Abstract]
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
1.4 nM
Compound: R(+)-SCH-23390
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Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs
Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs
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[PMID: 23403082] |
| HEK293 | IC50 |
2.52 nM
Compound: 1, SCH23390
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Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells
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[PMID: 22748706] |
| HTLA | IC50 |
162 nM
Compound: SCH-23390
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Antagonist activity at N-terminal Flag epitope tagged human dopamine D1 receptor expressed in HTLA cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition by luminescence
Antagonist activity at N-terminal Flag epitope tagged human dopamine D1 receptor expressed in HTLA cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition by luminescence
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[PMID: 37421373] |
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-0141084896
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
Chemical Information
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No. CAS 87075-17-0
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Peso molecular 287.78
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Fòrmula C17H18ClNO
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SMILES
OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1
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Synonyms
R-(+)-SCH-23390
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (34)
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Journal Impact Factor
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Most Recent
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Nat Commun
Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice. [Abstract]2026 Jun 16. PMID: 42303982 -
Nat Commun
Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. [Abstract]2024 Jun 10;15(1):4947. PMID: 38858350 -
Nat Commun
Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. [Abstract]2024 May 1;15(1):3685. PMID: 38693116 -
Nat Commun
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. [Abstract]2020 Feb 18;11(1):941. PMID: 32071304
SCH-23390 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).
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Microbiome
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice. [Abstract]2020 Aug 20;8(1):120. PMID: 32819434
SCH-23390 purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]
SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.
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Adv Sci (Weinh)
Dopamine D1 Receptor Contributes to Glucocorticoid-Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis. [Abstract]2025 Sep;12(33):e02276. PMID: 40583147 -
J Neuroinflammation
Dopamine signaling governs macrophage-mediated acute lung injury through JAML/IL-10-coupled mitochondrial regulation. [Abstract]2026 Apr 23. PMID: 42026623 -
J Hazard Mater
Early-life microplastic exposure elicits ADHD-like behaviors by disrupting dopaminergic neurodevelopment in zebrafish. [Abstract]2025 Sep 15:496:139466. PMID: 40779870 -
Acta Pharmacol Sin
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model. [Abstract]2026 Apr 24. PMID: 42032133 -
Acta Pharmacol Sin
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator. [Abstract]2024 Aug;45(8):1582-1590. PMID: 38605179
SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.
SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).
SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.
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Acta Pharmacol Sin
Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. [Abstract]2020 Feb;41(2):173-180. PMID: 31506572 -
Int J Biol Macromol
Structural and expression analysis of the dopamine receptors reveals their crucial roles in regulating the insulin signaling pathway in oysters. [Abstract]2023 Aug 30:247:125703. PMID: 37414315 -
Cell Rep
Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. [Abstract]2024 Sep 10;43(9):114717. PMID: 39264811 -
Neuropsychopharmacology
2024 Aug;49(9):1468-1480. PMID: 38734818 -
Biochem Pharmacol
2026 Feb:244:117576. PMID: 41319924 -
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Eur J Pharmacol
The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference. [Abstract]2024 Oct 15:981:176866. PMID: 39089461 -
Int Immunopharmacol
Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice. [Abstract]2020 Nov:88:106963. PMID: 33182028 -
Neurochem Int
Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. [Abstract]2023 Feb:163:105479. PMID: 36608872 -
J Psychiatry Neurosci
Reviving: restoring depression-like behaviour through glial cell-derived neurotrophic factor treatment in the medial prefrontal cortex. [Abstract]2024 Feb 1;49(1):E23-E34. PMID: 38302136 -
Brain Res Bull
DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. [Abstract]2021 Oct:175:136-149. PMID: 34284074 -
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J Neurosci
Potentiation of Nigra-Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed Mice. [Abstract]2025 Sep 3;45(36):e0382252025. PMID: 40769723 -
Insect Biochem Mol Biol
Molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis. [Abstract]2025 May:180:104312. PMID: 40245998 -
J Neurosci
Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit. [Abstract]2024 Aug 21;44(34):e0740242024. PMID: 39019613 -
Mol Brain
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum. [Abstract]2025 Jul 16;18(1):63. PMID: 40671088 -
Viruses
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3. [Abstract]2021 Aug 3;13(8):1533. PMID: 34452398 -
Psychopharmacology (Berl)
Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway. [Abstract]2022 Mar;239(3):951-964. PMID: 35190859 -
Biochem Biophys Res Commun
Expression changes of c-Fos and D1R/p-ERK1/2 signal pathways in nucleus accumbens of rats after ketamine abuse. [Abstract]2022 Nov 12:629:183-188. PMID: 36152451 -
Biochem Biophys Res Commun
2022 Jan 15:588:83-89. PMID: 34953210 -
Med Sci Monit
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons. [Abstract]2021 Oct 18;27:e933278. PMID: 34657931 -
Neurosci Lett
D1R/PP2A/p-CaMKIIα signaling in the caudate putamen is involved in acute methamphetamine-induced hyperlocomotion. [Abstract]2021 Aug 24:760:136102. PMID: 34237414 -
Behav Pharmacol
SKF82958, a dopamine D1 receptor agonist, disrupts prepulse inhibition in the medial prefrontal cortex and nucleus accumbens in C57BL/6J mice. [Abstract]2024 Jun 1;35(4):193-200. PMID: 38567425 -
bioRxiv
In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors. [Abstract]2024 Dec 23:2024.12.22.629999. PMID: 39763912
Pureza y Documentación
Referencias
[1]. Dakota B Zinani, et al. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Sci Rep. 2023 Sep 4;13(1):14566. [Content Brief]
[2]. J A Bourne, et al. SCH 23390: the first selective dopamine D1-like receptor antagonist. [Content Brief]
Calculators
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SCH-23390 Related Classifications
HY-19545 Related Classifications
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