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Referencia número: HY-120412

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SKLB188

SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC₅₀=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors.

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No. CAS: 1350545-09-3
Fòrmula: C₂₇H₃₁N₉O₂
Peso molecular:513.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SKLB188 Chemical Structure

No. CAS: 1350545-09-3

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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- Cellular Effect
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
HCC827	IC₅₀	<0.00001 μM Compound: 18a	Cytotoxicity against human HCC827 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCC827 cells incubated for 72 hrs by MTT assay	[PMID: 23116168]
HepG2	IC₅₀	>5 μM Compound: 18a	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 23116168]
NCI-H1975	IC₅₀	0.98 μM Compound: 18a	Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay	[PMID: 23116168]

Chemical Information

No. CAS 1350545-09-3
Peso molecular 513.59
Fòrmula C₂₇H₃₁N₉O₂
SMILES

O=[N+](C1=CC(NC2=NC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N2C6CCCC6)=CC=C1)[O-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Barzegar M, et al. SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling. Br J Cancer. 2017 Oct 10;117(8):1154-1163. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SKLB188

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SKLB188 Related Classifications

HY-120412 Related Classifications