STAT5-IN-3
Based on 2 publication(s) in Google Scholar
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C25H27N5O
- Peso molecular:413.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) STAT5-IN-3
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Actividad biológica
STAT5-IN-3 (Compound 14a) (100 nM-10 μM; 48 h) can inhibit the activity of myeloid leukemia cells (KU812, K562, KCL-22, MV-4-11, and MOLM-13) with EC50 values of 0.6 μM, 0.8 μM, 0.5 μM, 0.3 μM, and 0.3 μM, respectively. In contrast, STAT5-IN-3 exhibits low toxicity towards normal cells (HS27A and MSC), with EC50 values exceeding 10 μM for both cell types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 413.51
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Fòrmula C25H27N5O
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SMILES
CC(CC1)(C)C2=C(C=CC=C2C3=CN=C(N)N=C3)N1CCOC4=CC=C5C(C=CN5)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Phytother Res
(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy. [Abstract]2026 Apr 27. PMID: 42037203 -
J Ethnopharmacol
"Shihu" promote T-cell immunity against breast cancer through bioactive constituent THMB enhancing JAK3-STAT1 signal. [Abstract]2026 Oct 28:369:121888. PMID: 42202911
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT5-IN-3 Related Classifications
HY-170837 Related Classifications
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