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Referencia número: HY-N21964

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Sutherlandioside D

Sutherlandioside D is a natural product present in the aerial parts of Sutherlandia frutescens. Sutherlandioside D acts as an inhibitor of the Gli/hedgehog signaling pathway and exhibits reactive oxygen species (ROS) regulatory activity. Sutherlandioside D inhibits Gli reporter gene activity and reduces ROS production. Sutherlandioside D can be used in prostate cancer-related research.

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No. CAS: 1055329-49-1
Fòrmula: C₃₆H₅₈O₉
Peso molecular:634.84

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sutherlandioside D Chemical Structure

No. CAS: 1055329-49-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vitro

Sutherlandioside D (0.1-10 μg/mL; 48 h) potently inhibits Gli-reporter activity in stimulated Shh Light II cells with an IC₅₀ of 1.8 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1055329-49-1
Peso molecular 634.84
Fòrmula C₃₆H₅₈O₉
SMILES

O=C1[C@]23[C@@]4(C3)[C@]([C@H](C[C@@]2([H])C(C)(C=C1)C)O)([H])[C@]5([C@](CC4)([C@@](CC5)([H])[C@H](C)CC[C@H](O)C(C)(C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C)C
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Avula B, et al. Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method. J Pharm Biomed Anal. 2010 Jun 5;52(2):173-80.

[2]. Lin H, et al. Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract. Cell biology international. 2016 Feb;40(2):131-42. [Content Brief]

[3]. Lei W, et al. Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages. International immunopharmacology. 2015 Dec;29(2):254-262.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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