SW016789
Based on 1 Customer Validation
SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction.
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- Pureza: 99.85%
- No. CAS: 292613-04-8
- Fòrmula: C20H19N3OS
- Peso molecular:349.45
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Anti-diabetic Compound Library
HY-L040
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Endocrinology Compound Library
HY-L047
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Highly Selective Activators Library
HY-L159
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Ion Channel Compound Library
HY-L166
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
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VDAC1 |
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Cell Line
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Type | Value | Description | References |
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| CHO-K1 | EC50 |
19.1 μM
Compound: 17
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Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintillation counting
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintillation counting
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[PMID: 21090651] |
SW016789 (5 μM; 0-24 h) can enhance insulin secretion stimulated by glucose within a short period of time (1-2 h), but results in loss of β cell function after longer exposure (4-24 h) in MIN6 cells[2].
SW016789 (5 μM; 24-72 h) does not affect beta cell viability or apoptosis in MIN6 cells[2].
SW016789 (5 μM; 24h) enhances nutrient-stimulated Ca2+ influx to elicit hypersecretion, VDAC1 is a pharmacological target for insulin hypersecretion in mouse MIN6 cells and human EndoC-βH1 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MIN6
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Concentration:5 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Did not alter relative amounts of live cells, dead cells, or the live/dead cell ratio.
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Cell Line:MIN6
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Concentration:5 μM
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Incubation Time:24 h
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Result:Caused loss of function alone or in combination with eeyarestatin I (ES1) (HY-110078).
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Cell Line:Mouse MIN6; human EndoC-βH1
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Concentration:5 μM
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Incubation Time:1 h, 2 h, 4 h, 6 h, 24 h
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Result:Induced the immediate-early response and did not robustly engage canonical ER stress pathways.
Chemical Information
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No. CAS 292613-04-8
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Appearance Solid
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Peso molecular 349.45
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Fòrmula C20H19N3OS
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Color White to off-white
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SMILES
N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (143.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Roy G, et al. VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells. Cell Rep. 2025 Jun 24;44(6):115834. [Content Brief]
[2]. Rodrigues-Dos-Santos K et, al. Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function. Endocrinology. 2022 Jul 1;163(7):bqac081. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8616 mL | 14.3082 mL | 28.6164 mL | 71.5410 mL |
| 5 mM | 0.5723 mL | 2.8616 mL | 5.7233 mL | 14.3082 mL | |
| 10 mM | 0.2862 mL | 1.4308 mL | 2.8616 mL | 7.1541 mL | |
| 15 mM | 0.1908 mL | 0.9539 mL | 1.9078 mL | 4.7694 mL | |
| 20 mM | 0.1431 mL | 0.7154 mL | 1.4308 mL | 3.5770 mL | |
| 25 mM | 0.1145 mL | 0.5723 mL | 1.1447 mL | 2.8616 mL | |
| 30 mM | 0.0954 mL | 0.4769 mL | 0.9539 mL | 2.3847 mL | |
| 40 mM | 0.0715 mL | 0.3577 mL | 0.7154 mL | 1.7885 mL | |
| 50 mM | 0.0572 mL | 0.2862 mL | 0.5723 mL | 1.4308 mL | |
| 60 mM | 0.0477 mL | 0.2385 mL | 0.4769 mL | 1.1923 mL | |
| 80 mM | 0.0358 mL | 0.1789 mL | 0.3577 mL | 0.8943 mL | |
| 100 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.7154 mL |
SW016789 Related Classifications
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