Vexicitinib
Vexicitinib (Vexicitinibum) is a SYK and JAK2 inhibitor with IC50 values both less than 10 nM. Vexicitinib exhibits anti-inflammatory and immunosuppressive effects. Vexicitinib can be used in tumor-related research.
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- No. CAS: 2230362-69-1
- Fòrmula: C22H27N7O4S
- Peso molecular:485.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
JAK2 <10 nM (IC50) |
Syk <10 nM (IC50) |
In Vitro
Vexicitinib (Compound C10R) potently inhibits purified SYK protein kinase activity with an IC50 of <10 nM[2].
Vexicitinib potently inhibits purified JAK2 protein kinase activity with an IC50 of <10 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | Tmax | T1/2 | Cmax | AUC0-24 |
|---|---|---|---|---|---|---|
| Mice[2] | 5 mg/kg | p.o. | 0.5 h | 2.41 h | 451.36 ng/mL | 1243.51 ng/mL·h |
Chemical Information
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No. CAS 2230362-69-1
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Peso molecular 485.56
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Fòrmula C22H27N7O4S
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SMILES
O=S(N1C[C@@]2([H])N(CC1)C3=CC=C(NC4=NC=C(C(N)=O)C(NC5CC5)=N4)C=C3OC2)(C6CC6)=O
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Synonyms
Vexicitinibum
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Vexicitinib Related Classifications
HY-184063 Related Classifications
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