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Referencia número: HY-155774

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VU533

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC₅₀ value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.84%
No. CAS: 923417-09-8
Fòrmula: C₂₁H₂₂FN₃O₃S₂
Peso molecular:447.55

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

VU533 Chemical Structure

No. CAS: 923417-09-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

PLD1

0.3 μM (EC₅₀)

Ver todos los productos específicos de isoformas Phospholipase :

In Vitro

NAPE-PLD activator (VU533) (0.1-30 μM, 24 h) has no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells^[1].
NAPE-PLD activator (0.1-30 μM, 24 h) increases Nape-pld activity in a concentration-dependent manner in RAW264.7 cells and HepG2 cells^[1].
NAPE-PLD activator (10 μM, 6 h) enhances efferocytosis in bone-marrow derived macrophages (BMDM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

RAW264.7, HepG2
Concentration:

0.1-30 μM
Incubation Time:

24 h
Result:

Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells.

Cell Autophagy Assay^[1]

Cell Line:

BMDM
Concentration:

10 μM
Incubation Time:

6 h
Result:

Enhanced efferocytosis compared to vehicle treated BMDM at 10μM.

Chemical Information

No. CAS 923417-09-8
Appearance Solid
Peso molecular 447.55
Fòrmula C₂₁H₂₂FN₃O₃S₂
Color White to off-white
SMILES

CC1=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C(C)C=C1
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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ACS Nano

Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism. [Abstract]

2025 Mar 11;19(9):9390-9411. PMID: 40025734

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (279.30 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2344 mL

11.1719 mL

22.3439 mL

5 mM

0.4469 mL

2.2344 mL

4.4688 mL

10 mM

0.2234 mL

1.1172 mL

2.2344 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2344 mL	11.1719 mL	22.3439 mL	55.8597 mL
	5 mM	0.4469 mL	2.2344 mL	4.4688 mL	11.1719 mL
	10 mM	0.2234 mL	1.1172 mL	2.2344 mL	5.5860 mL
	15 mM	0.1490 mL	0.7448 mL	1.4896 mL	3.7240 mL
	20 mM	0.1117 mL	0.5586 mL	1.1172 mL	2.7930 mL
	25 mM	0.0894 mL	0.4469 mL	0.8938 mL	2.2344 mL
	30 mM	0.0745 mL	0.3724 mL	0.7448 mL	1.8620 mL
	40 mM	0.0559 mL	0.2793 mL	0.5586 mL	1.3965 mL
	50 mM	0.0447 mL	0.2234 mL	0.4469 mL	1.1172 mL
	60 mM	0.0372 mL	0.1862 mL	0.3724 mL	0.9310 mL
	80 mM	0.0279 mL	0.1396 mL	0.2793 mL	0.6982 mL
	100 mM	0.0223 mL	0.1117 mL	0.2234 mL	0.5586 mL

Keywords

VU533

1 Cited Publications

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

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VU533

Metabolism/Protease Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

Macrophage Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) VU533

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

VU533

Metabolism/Protease Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

Macrophage Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) VU533

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

VU533 Related Classifications

HY-155774 Related Classifications