Gefitinib-d8
Based on 1 Customer Validation
Gefitinib-d8 (ZD1839-d8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.
For research use only. We do not sell to patients.
- Purity: 98.42%
- CAS No.: 857091-32-8
- Formula: C22H16D8ClFN4O3
- Molecular Weight:454.95
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 857091-32-8
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Unlabeled Cas 184475-35-2
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Appearance Solid
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Molecular Weight 454.95
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Formula C22H16D8ClFN4O3
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Color White to off-white
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SMILES
[2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)C1([2H])[2H]
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Synonyms
ZD1839-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (274.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (923 KB)
- English - EN (923 KB)
- Français - FR (923 KB)
- Deutsch - DE (923 KB)
- Norwegian - NO (923 KB)
- Español - ES (923 KB)
- Swedish - SV (923 KB)
- Italian - IT (923 KB)
- Portuguese - PT (923 KB)
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Handling Instructions (2659 KB)
References
[1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [Content Brief]
[2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1980 mL | 10.9902 mL | 21.9804 mL | 54.9511 mL |
| 5 mM | 0.4396 mL | 2.1980 mL | 4.3961 mL | 10.9902 mL | |
| 10 mM | 0.2198 mL | 1.0990 mL | 2.1980 mL | 5.4951 mL | |
| 15 mM | 0.1465 mL | 0.7327 mL | 1.4654 mL | 3.6634 mL | |
| 20 mM | 0.1099 mL | 0.5495 mL | 1.0990 mL | 2.7476 mL | |
| 25 mM | 0.0879 mL | 0.4396 mL | 0.8792 mL | 2.1980 mL | |
| 30 mM | 0.0733 mL | 0.3663 mL | 0.7327 mL | 1.8317 mL | |
| 40 mM | 0.0550 mL | 0.2748 mL | 0.5495 mL | 1.3738 mL | |
| 50 mM | 0.0440 mL | 0.2198 mL | 0.4396 mL | 1.0990 mL | |
| 60 mM | 0.0366 mL | 0.1832 mL | 0.3663 mL | 0.9159 mL | |
| 80 mM | 0.0275 mL | 0.1374 mL | 0.2748 mL | 0.6869 mL | |
| 100 mM | 0.0220 mL | 0.1099 mL | 0.2198 mL | 0.5495 mL |
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