1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Autophagy
  2. EGFR
    Autophagy
  3. Gefitinib D8

Gefitinib D8 (Synonyms: ZD1839 D8)

Cat. No.: HY-50895S
Handling Instructions

Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.

For research use only. We do not sell to patients.

Gefitinib D8 Chemical Structure

Gefitinib D8 Chemical Structure

CAS No. : 857091-32-8

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Description

Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

IC50 & Target

IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]

Molecular Weight

454.95

Formula

C₂₂H₁₆D₈ClFN₄O₃

CAS No.

857091-32-8

SMILES

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)C1([2H])[2H]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gefitinib D8ZD1839 D8Gefitinib D 8Gefitinib D-8EGFRAutophagyEpidermal growth factor receptorErbB-1HER1DeuteriumlabeledGefitinibInhibitorinhibitorinhibit

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