CCL26 - C-C motif chemokine ligand 26 Gene

Also Known as IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10344

About CCL26

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,769,524-75,791,597 (from NCBI)

This gene has 2 transcripts (splice variants), 81 orthologues and 25 paralogues. Broad expression in ovary (RPKM 2.0), adrenal (RPKM 0.7) and 14 other tissues.

Summary

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an Antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate Chemokine Receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]

CCL26 Products (3)

mRNA	Protein	Name
NM_001371936.1	NP_001358865.1	C-C motif chemokine 26 precursor
NM_001371938.1	NP_001358867.1	C-C motif chemokine 26 precursor
NM_006072.4	NP_006063.1	C-C motif chemokine 26 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	11425309	GOA
enables CX3C chemokine receptor binding	IDA IDA: Inferred from direct assay	20974991	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	10373330	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11425309	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10373330	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19525930	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10373330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL26 Protein Structure

IL8

0
94 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 26	CC chemokine IMAC

CCL26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL26	Q9Y258	XCL1	Homo sapiens	P47992	Filter Binding	28381538
Intra	CCL26	Q9Y258	CCL17	Homo sapiens	Q92583	SPR	28381538
Intra	CCL26	Q9Y258	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CCL26	Q9Y258	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	CCL26	Q9Y258	CXCL14	Homo sapiens	O95715	Filter Binding	28381538
Intra	CCL26	Q9Y258	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL26	Q9Y258	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL26	Q9Y258	CXCL11	Homo sapiens	O14625	Filter Binding	28381538
Intra	CCL26	Q9Y258	CXCL9	Homo sapiens	Q07325	Filter Binding	28381538
Intra	CCL26	Q9Y258	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CCL26	Q9Y258	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CCL26	Q9Y258	CCL13	Homo sapiens	Q99616	Filter Binding	28381538
Intra	CCL26	Q9Y258	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	CCL26	Q9Y258	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	CCL26	Q9Y258	CCL28	Homo sapiens	Q9NRJ3	Filter Binding	28381538
Intra	CCL26	Q9Y258	CXCL10	Homo sapiens	P02778	Filter Binding	28381538
Intra	CCL26	Q9Y258	CCL21	Homo sapiens	O00585	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL26 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7163	Eotaxin-3/CCL26 Protein, Human	Q9Y258 (T24-L94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75606	Eotaxin-3/CCL26 Protein, Human (sf9)	Q9Y258 (T24-L94)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Esophagitis	Acute Esophagitis
Heart Tumor	Intracavitary Tumors Myocardial Tumors Primary Cardiac Tumors, Childhood Heart Neoplasm Intracavitary Tumors Of The Heart Neoplasm Of Myocardium
Churg-Strauss Syndrome	Eosinophilic Granulomatosis With Polyangiitis Allergic Granulomatous Angiitis Churg-Strauss Vasculitis Allergic Angiitis Egpa Granulomatous Allergic Angiitis Allergic Granulomatosis Angiitis Allergic Angiitis And Granulomatosis Allergic Granulomatosis Allergic Granulomatous And Angiitis Css
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Eosinophilic Gastritis	Eosinophilic Enteropathy
Angiomyolipoma	Angiomyolipoma Of Kidney
Congenital Heart Defects, Hamartomas Of Tongue, And Polysyndactyly	Ostravik-Lindemann-Solberg Syndrome CHDTHP Heart Defect-Tongue Hamartoma-Polysyndactyly Syndrome Orstavik Lindemann Solberg Syndrome Heart Defect - Tongue Hamartoma - Polysyndactyly Syndrome Heart Defect, Tongue Hamartoma And Polysyndactyly Hamartoma
Tuberous Sclerosis 1	Tuberous Sclerosis Complex Tuberous Sclerosis Bourneville Syndrome TSC1 Tuberose Sclerosis Ts Tuberous Sclerosis-1 Bourneville Disease Tsc Bourneville Phakomatosis Cerebral Sclerosis Sclerosis Tuberosa Tuberous Sclerosis, Type 1
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Eosinophilic Gastroenteritis	Eosinophilic Enteritis Ege Eosinophilic Gastroenterocolitis Eosinophilic Esophagitis Eosinophilic Gastritis Eosinophilic Gastroenteropathy Gastroenteritis, Eosinophilic Eosinophilic Enteropathy
Esophageal Candidiasis	Candidiasis Of The Esophagus Candida Esophagitis Candidal Esophagitis Esophageal Moniliasis Esophageal Thrush
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Monkeypox	Monkeypox Virus Infections
Peptic Esophagitis	Reflux Esophagitis Peptic Reflux Disease Reflux Oesophagitis Esophagitis, Peptic Gastro-Esophageal Reflux Disease With Esophagitis
Gastroduodenitis
Abcd Syndrome	ABCDS Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Nasal Cavity Disease	Disorder Of Nasal Cavity
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Respiratory Allergy	Airway Allergy
Common Cold	Acute Coryza Acute Nasopharyngitis Acute Rhinitis Acute Viral Rhinopharyngitis Nasopharyngitis - Acute Nasopharyngitis, Acute Rhino-Sinusitis Rhinosinusitis Common Colds Acute Infective Rhinitis Cold Coryza Head Cold Infective Nasopharyngitis Rhinopharyngitis Acute Nasal Catarrh Infective Rhinitis Acute Nasopharyngeal Catarrh Infective Nasopharyngitis Nos Nasopharyngitis Nos Epipharyngitis Mucositis Nos Inflammatory Disease Of Mucous Membrane Mucosal Inflammation
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136788	ALK4290	Inhibitor	99.79%	Unkown
HY-RS02096	CCL26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174756	Human CCL26 mRNA		/	Unkown
HY-RS18380	Ccl26 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24860	Ccl26 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL26	MGD	MGI:3589281
Canis familiaris	CCL26	VGNC	VGNC:38888
Bos taurus	CCL26	VGNC	VGNC:106677
Felis catus	CCL26	VGNC	VGNC:107744
Macaca mulatta	CCL26	VGNC	VGNC:70701
Rattus norvegicus	CCL26	RGD	RGD:1587817
Others	CCL26	NCBI