IFITM3 - interferon induced transmembrane protein 3 Gene

Also Known as 1-8U; IP15; DSPA2b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10410

About IFITM3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:319,676-320,860 (from NCBI)

This gene has 27 transcripts (splice variants), 243 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 370.9), placenta (RPKM 358.2) and 25 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM3 Products (1)

mRNA	Protein	Name
NM_021034.3	NP_066362.2	interferon-induced transmembrane protein 3

IFITM3 Protein Structure

CD225

0
100
133 a.a.

Protein Preferred Names	Protein Names
interferon-induced transmembrane protein 3	dispanin subfamily A member 2b

IFITM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	IFITM3	Q01628	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	IFITM3	Q01628	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	IFITM3	Q01628	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Validated Y2H	32296183
Intra	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
Intra	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Y2H Array	32296183
Intra	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Validated Y2H	32296183
Intra	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Validated Y2H	32296183
Intra	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	NAMPT	Homo sapiens	P43490	Y2H	18486613
Intra	IFITM3	Q01628	NAMPT	Homo sapiens	P43490	Anti Bait CoIP	18486613
Intra	IFITM3	Q01628	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	IFITM3	Q01628	BRI3	Homo sapiens	O95415	Anti Tag CoIP	30983867
Intra	IFITM3	Q01628	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	IFITM3	Q01628	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	IFITM3	Q01628	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	IFITM3	Q01628	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Anti Tag CoIP	33961781
Intra	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	IFITM3	Q01628	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFITM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77370	IFITM3/Fragilis Protein, Human (HEK293, Fc)	Q01628/NP_066362.2 (M1-H57)	≥ 95%, as determined by reducing SDS-PAGE.

IFITM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83115	Fragilis Antibody (YA2860)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P83115A	Fragilis Antibody (YA2860)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P86615	IFITM3 Antibody (YA6307)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Influenza, Severe	Influenza, Severe, Susceptibility To
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Stomatitis
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Rift Valley Fever	Rfv - [Rift Valley Fever]
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Mouth Disease	Mouth Diseases Mouth Disorders
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-U00434	3BDO		99.93%	Unkown
HY-RS06568	IFITM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179548	Photoclick palmitic acid		/	Unkown
HY-RS17924	Ifitm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24394	Ifitm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFITM3	MGD	MGI:1913391
Rattus norvegicus	IFITM3	RGD	RGD:1595844
Others	IFITM3	NCBI