Rars - arginyl-tRNA synthetase Gene

Also Known as Rars1; 2610011N19Rik; 2610037E21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104458

Summary

Enables arginine-tRNA Ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rars Products (1)

mRNA Protein Name
NM_025936.3 NP_080212.2 arginine--tRNA ligase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arginine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
Biological Process GO Annotation Evidence References Source
involved in arginyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
12060739 MGI
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arginine--tRNA ligase, cytoplasmic

  • argRS

  • arginyl-tRNA synthetase, cytoplasmic

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14649 Retinoic acid Agonist 99.81% Unkown
HY-14171 Bexarotene 99.90% Yes
HY-14652 Tamibarotene 99.57% Yes
HY-15128 9-cis-Retinoic acid 99.92% Unkown
HY-14649R Retinoic acid (Standard) Agonist 99.73% Unkown
HY-B0091 Adapalene 99.94% Yes
HY-15373 Fenretinide 98.56% Yes
HY-14799 Palovarotene Agonist 99.81% Yes
HY-15388 Tazarotene Agonist 99.17% Unkown
HY-100256 Trifarotene Agonist 99.12% Yes
HY-100008 Peretinoin 99.79% Unkown
HY-101108 Tazarotenic acid 98.67% Unkown
HY-15388R Tazarotene (Standard) Agonist 98.75% Unkown
HY-15373R Fenretinide (Standard) / Unkown
HY-B0091R Adapalene (Standard) / Unkown
HY-B0091A Adapalene sodium salt 99.69% Yes

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-14649G Retinoic acid (GMP) Agonist / Phase 3
HY-13717 AGN194204 99.79% Phase 2
HY-12887 Piclamilast Inhibitor 99.74% Phase 2
HY-16684 AGN-195183 Agonist 99.75% Phase 2
HY-14653 Amsilarotene 99.67% Phase 2
HY-106963 ALRT1550 Agonist / Phase 2
HY-15340 LG100268 99.39% Phase 1

Pre-clinical Phase

Bioactive Molecules (97)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15682 TTNPB 99.85% Unkown
HY-108529 BMS493 Inhibitor 99.73% Unkown
HY-10475 AM580 99.70% Unkown
HY-U00449 AGN 193109 Antagonist 99.80% Unkown
HY-101106 AR7 Antagonist 99.38% Unkown
HY-100532 CD437 Agonist 98.76% Unkown
HY-116248 Ro 41-5253 98.97% Unkown
HY-16681 AGN 194310 Antagonist 98.07% Unkown
HY-107436 LE135 99.0% Unkown
HY-108527 CD1530 98.01% Unkown
HY-107765 LY2955303 Antagonist 99.80% Unkown
HY-100608 BMS453 Modulator 99.85% Unkown
HY-107397 Ch55 Agonist 99.86% Unkown
HY-108530 MM11253 Antagonist 98.21% Unkown
HY-107395 BMS 753 Agonist ≥99.0% Unkown
HY-107437 CD2665 Antagonist 99.68% Unkown
HY-107494A all-trans-4-Oxoretinoic acid 98.03% Unkown
HY-108533 CD2314 Agonist ≥99.0% Unkown
HY-101259 BMS-195614 99.5% Unkown
HY-50081 CCR2-RA-[R] Antagonist 99.21% Unkown
HY-14649S4 Retinoic acid-d5 Agonist 99.07% Unkown
HY-111573 KCL-286 Agonist 98.93% Unkown
HY-127024 Thyroid hormone receptor antagonist (1-850) Antagonist 99.04% Unkown
HY-108531 ER 50891 Antagonist 98.59% Unkown
HY-16682 AGN 196996 Antagonist 99.76% Unkown
HY-16683 AGN 205728 Antagonist 98.62% Unkown
HY-119518 BMS641 Agonist 98.12% Unkown
HY-125904 4-Hydroxyretinoic acid ≥95.0% Unkown
HY-100273 AGN 194078 Agonist 99.87% Unkown
HY-108528 BMS961 Agonist 98.06% Unkown
HY-124136 WYC-209 99.82% Unkown
HY-108526 AC-55649 Agonist 99.70% Unkown
HY-149085 XS-060 Antagonist 98.67% Unkown
HY-132334S 9-cis-Retinoic acid-d5 99.24% Unkown
HY-105689 AGN 192870 Antagonist 98.49% Unkown
HY-108531A ER 50891 quarterhydrate Antagonist 99.86% Unkown
HY-114071 BMS270394 Agonist 98.0% Unkown
HY-156280 RARα antagonist 1 Antagonist 99.07% Unkown
HY-173614 CC-647 Modulator 99.58% Unkown
HY-W442049 Hydroxypinacolone retinoate Agonist 99.33% Unkown
HY-111844 PROTAC RAR Degrader-1 Inhibitor 97.91% Unkown
HY-D1190 DC271 Agonist 97.7% Unkown
HY-106735 Arotinoid Agonist 99.55% Unkown
HY-117545 LE-540 Antagonist 99.74% Unkown
HY-170786 IRX5010 Agonist 98.85% Unkown
HY-170863 ZSH-2208 Agonist 99.90% Unkown
HY-14649S3 Retinoic acid-d6 98.9% Unkown
HY-10475G AM580 (GMP) Agonist / Unkown
HY-15682G TTNPB (GMP) Agonist / Unkown
HY-W587468 all-trans-3,4-Didehydro retinoic acid 95.0% Unkown
HY-19878 Seletinoid G Agonist 90.86% Unkown
HY-165521 AGN-190121 / Unkown
HY-U00449G AGN 193109 (GMP) Antagonist / Unkown
HY-15388S Tazarotene-d8 Agonist / Unkown
HY-B0091S Adapalene-d3 / Unkown
HY-U00449S AGN 193109-d7 Antagonist / Unkown
HY-100256S Trifarotene-d4 Agonist / Unkown
HY-100532S CD437-13C6 Agonist / Unkown
HY-101108S Tazarotenic acid-d6 / Unkown
HY-101108S1 Tazarotenic acid-13C2,d2 / Unkown
HY-111843 Ch55-O-C3-NH2 / Unkown
HY-117227 NRX-204647 Activator / Unkown
HY-118761 5,6-Epoxyretinoic acid Agonist 95.46% Unkown
HY-119080 CP8754 Antagonist / Unkown
HY-120130 BMS-948 Agonist / Unkown
HY-12798E (R)-AR-13503 Control 98.20% Unkown
HY-14649S5 Retinoic acid-d3 Agonist / Unkown
HY-15388S1 Tazarotene-13C2,d2 / Unkown
HY-162827 RAR/RXR agonist-1 / Unkown
HY-167262 AGN-191659 Agonist / Unkown
HY-168318 Bestatin-amide-PEG3-CH2-acid / Unkown
HY-168885 ZSH-512 98.37% Unkown
HY-169863 DC360 Agonist / Unkown
HY-173159 BMS-185354 Activator / Unkown
HY-180323 ER-38925 Agonist / Unkown
HY-180409 YM580 Antagonist / Unkown
HY-183139 CD666 / Unkown
HY-183986 SR210831C Inhibitor / Unkown
HY-186156 RARγ antagonist 1 Antagonist / Unkown
HY-187422 RS-2982 / Unkown
HY-RS11676 RARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11677 RARS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00449A AGN 193109 sodium Antagonist / Unkown
HY-W752012 Adapalene-13C6 / Unkown
HY-W777169 Bexarotene-13C4 / Unkown
HY-W816575 MDI-403 / Unkown
HY-107810 Methyl 13-cis-4-oxoretinoate Agonist 96.77% Unkown
HY-118364 AGN 190727 / Unkown
HY-118420 BMS-185411 Antagonist / Unkown
HY-14171S2 Bexarotene-13C6 / Unkown
HY-14649S2 11-cis-Retinoic Acid-d5 Agonist / Unkown
HY-14649S6 Retinoic acid-d3-1 Agonist / Unkown
HY-15388S2 Tazarotene-13C6 Agonist / Unkown
HY-15388S3 Tazarotene-d6 / Unkown
HY-16685 AGN 205327 Agonist / Unkown
HY-183405 CD2019 Agonist / Unkown
HY-107218 11-Hydroxysugiol Modulator / Unkown