OLFM4 - olfactomedin 4 Gene

Also Known as GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10562

About OLFM4

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:53,028,813-53,052,057 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues and 9 paralogues. Biased expression in small intestine (RPKM 721.2), duodenum (RPKM 639.8) and 4 other tissues.

Summary

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

OLFM4 Products (1)

mRNA Protein Name
NM_006418.5 NP_006409.3 olfactomedin-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding IMP
IMP: Inferred from mutant phenotype
16566923 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20534456 GOA
enables structural molecule activity IDA
IDA: Inferred from direct assay
16566923 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
16566923 GOA
Cellular Component GO Annotation Evidence References Source
NOT located in azurophil granule IDA
IDA: Inferred from direct assay
23922742 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
23922742 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
16566923 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16566923 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16566923 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
16566923 GOA
NOT located in secretory granule IDA
IDA: Inferred from direct assay
23922742 GOA
located in specific granule IDA
IDA: Inferred from direct assay
23922742 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM4 Protein Structure

OLF

OLF: Olfactomedin-like domain (251 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

olfactomedin-4

  • G-CSF-stimulated clone 1 protein

OLFM4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OLFM4 Q6UX06 LDLRAD1 Homo sapiens Q5T700
Y2H Array
25416956
Intra
OLFM4 Q6UX06 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
OLFM4 Q6UX06 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 LDLRAD1 Homo sapiens Q5T700
Y2H Array
31515488
Intra
OLFM4 Q6UX06 NOD1 Homo sapiens Q9Y239
Anti Tag CoIP
20534456
Intra
OLFM4 Q6UX06 CLSTN3 Homo sapiens Q9BQT9
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLSTN3 Homo sapiens Q9BQT9
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 CLSTN3 Homo sapiens Q9BQT9
Y2H Array
32296183
Intra
OLFM4 Q6UX06 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra
OLFM4 Q6UX06 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
OLFM4 Q6UX06 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLEC7A Homo sapiens Q9BXN2-6
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLEC7A Homo sapiens Q9BXN2-6
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 CLEC7A Homo sapiens Q9BXN2-6
Y2H Array
32296183
Intra
OLFM4 Q6UX06 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
OLFM4 Q6UX06 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
OLFM4 Q6UX06 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
OLFM4 Q6UX06 ITM2C Homo sapiens Q9NQX7-3
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 ITM2C Homo sapiens Q9NQX7-3
Y2H Array
32296183
Intra
OLFM4 Q6UX06 ITM2C Homo sapiens Q9NQX7-3
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 QPCTL Homo sapiens Q9NXS2-3
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 QPCTL Homo sapiens Q9NXS2-3
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 QPCTL Homo sapiens Q9NXS2-3
Y2H Array
32296183
Intra
OLFM4 Q6UX06 IL11RA Homo sapiens Q14626
Y2H Array
32296183
Intra
OLFM4 Q6UX06 IL11RA Homo sapiens Q14626
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 EREG Homo sapiens O14944
Y2H Array
32296183
Intra
OLFM4 Q6UX06 EREG Homo sapiens O14944
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
OLFM4 Q6UX06 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
OLFM4 Q6UX06 LHFPL2 Homo sapiens Q6ZUX7
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 LHFPL2 Homo sapiens Q6ZUX7
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 LHFPL2 Homo sapiens Q6ZUX7
Y2H Array
32296183
Intra
OLFM4 Q6UX06 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
OLFM4 Q6UX06 TSPAN18 Homo sapiens Q8WUV1
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 TSPAN18 Homo sapiens Q8WUV1
Y2H Array
32296183
Intra
OLFM4 Q6UX06 TSPAN18 Homo sapiens Q8WUV1
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 PVRIG Homo sapiens Q6DKI7
Y2H Array
32296183
Intra
OLFM4 Q6UX06 PVRIG Homo sapiens Q6DKI7
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
OLFM4 Q6UX06 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
OLFM4 Q6UX06 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra
OLFM4 Q6UX06 AQP3 Homo sapiens Q92482
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 AQP3 Homo sapiens Q92482
Y2H Array
32296183
Intra
OLFM4 Q6UX06 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
OLFM4 Q6UX06 CLTRN Homo sapiens Q9HBJ8
Y2H Array
32296183
Intra
OLFM4 Q6UX06 CLTRN Homo sapiens Q9HBJ8
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLTRN Homo sapiens Q9HBJ8
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 TFR2 Homo sapiens Q9UP52
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 TFR2 Homo sapiens Q9UP52
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 TFR2 Homo sapiens Q9UP52
Y2H Array
32296183
Intra
OLFM4 Q6UX06 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
OLFM4 Q6UX06 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
OLFM4 Q6UX06 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
OLFM4 Q6UX06 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra
OLFM4 Q6UX06 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
OLFM4 Q6UX06 TNFSF11 Homo sapiens O14788
Y2H Array
32296183
Intra
OLFM4 Q6UX06 TNFSF11 Homo sapiens O14788
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
OLFM4 Q6UX06 NOD2 Homo sapiens Q9HC29
Anti Tag CoIP
20534456
Intra
OLFM4 Q6UX06 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra
OLFM4 Q6UX06 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
OLFM4 Q6UX06 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OLFM4 Proteins

Cat. No. Product Name Accession Purity
HY-P71179 OLFM4 Protein, Human (HEK293, His) Q6UX06 (D21-Q510) ≥ 80%, as determined by reducing SDS-PAGE.

OLFM4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82543 Olfactomedin 4 Antibody (YA2288) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Atrophy Of Prostate
Colonic Benign Neoplasm

  • Colon Neoplasm

  • Colonic Mass

  • Colonic Tumor

  • Neoplasm Of Colon

  • Neoplasm Of The Colon

  • Colonic Neoplasms

  • Colon Cancer

  • Colon Carcinoma Nos

  • Colonic Cancer

  • Metastatic Colon Cancer Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09773 OLFM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19224 Olfm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25713 Olfm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OLFM4 VGNC VGNC:75418
Rattus norvegicus OLFM4 RGD RGD:1311708
Canis familiaris OLFM4 VGNC VGNC:49706
Bos taurus OLFM4 VGNC VGNC:32420
Felis catus OLFM4 VGNC VGNC:63961
Mus musculus OLFM4 MGD MGI:2685142
Others OLFM4 NCBI