Vip - vasoactive intestinal peptide Gene

Also Known as vip/phi27

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117064

Summary

Enables hormone activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; and positive regulation of penile erection. Located in neuronal cell body. Used to study several diseases, including Parkinsonism; brain ischemia; periodontitis; pulmonary hypertension; and uveitis. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Apr 2022]

Vip Products (1)

mRNA Protein Name
NM_053991.1 NP_446443.1 VIP peptides preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
9603988 RGD
enables signaling receptor binding IDA
IDA: Inferred from direct assay
1314625 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9603988 RGD
involved in learning or memory IDA
IDA: Inferred from direct assay
19465061 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21850490 RGD
involved in negative regulation of potassium ion transport IDA
IDA: Inferred from direct assay
20699230 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20452385 RGD
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
19332106 RGD
involved in positive regulation of penile erection IDA
IDA: Inferred from direct assay
21166748 RGD
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
9603988 RGD
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
9603988 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
22108610 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

VIP peptides

  • vasoactive intestinal polypeptide

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0012 Aviptadil Inhibitor 99.95% Unkown
HY-P0012A Aviptadil acetate Inhibitor 99.87% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-103019B (-)-Enitociclib 99.85% Phase 1
HY-164429 VIP236 / Phase 1
HY-103019BR (-)-Enitociclib (Standard) / Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0221 PACAP (1-38), human, ovine, rat Inducer 99.99% Unkown
HY-103019 Enitociclib 99.89% Unkown
HY-P0220A PACAP (6-38), human, ovine, rat TFA 99.89% Unkown
HY-P5005 VIPhyb 99.82% Unkown
HY-P0221C PACAP (1-38) free acid 99.94% Unkown
HY-P1023 VIP(6-28)(human, rat, porcine, bovine) Antagonist 98.09% Unkown
HY-P0220 PACAP (6-38), human, ovine, rat 99.98% Unkown
HY-103019A (±)-Enitociclib 99.23% Unkown
HY-P4776 Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) Antagonist 98.01% Unkown
HY-P4127A M65 TFA Inhibitor 99.98% Unkown
HY-P4195A [K15,R16,L27]VIP(1-7)/GRF(8-27) acetate Agonist 99.50% Unkown
HY-P1159A [D-p-Cl-Phe6,Leu17]-VIP TFA 98.16% Unkown
HY-P1015 VIP(Guinea pig) Ligand 98.66% Unkown
HY-P11288A ANT308 TFA 99.57% Unkown
HY-P10768A Ro 25-1553 TFA Agonist 99.17% Unkown
HY-P3117 PACAP (6-27) (human, ovine, rat) Antagonist 99.36% Unkown
HY-P10948A CS-VIP 8 hydrochloride Inhibitor 96.04% Unkown
HY-P10768B Ro 25-1553 acetate Agonist 98.17% Unkown
HY-P4195 [K15,R16,L27]VIP(1-7)/GRF(8-27) Agonist / Unkown
HY-172680 DSPE-PEG1000-VIP / Unkown
HY-172681 DSPE-PEG2000-VIP / Unkown
HY-172681A DSPE-PEG3400-VIP / Unkown
HY-172682 DSPE-PEG5000-VIP / Unkown
HY-P0211 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Antagonist / Unkown
HY-P0221A PACAP (1-38), human, ovine, rat TFA Inducer / Unkown
HY-P0221B PACAP (1-38) free acid TFA / Unkown
HY-P1015A VIP(Guinea pig) TFA Ligand / Unkown
HY-P10768 Ro 25-1553 Agonist / Unkown
HY-P10948 CS-VIP 8 Inhibitor / Unkown
HY-P11288 ANT308 / Unkown
HY-P1158 [Ala2,8,9,11,19,22,24,25,27,28]-VIP / Unkown
HY-P1159 [D-p-Cl-Phe6,Leu17]-VIP Antagonist / Unkown
HY-P1767 Prepro VIP (81-122), human / Unkown
HY-P2702 Helodormin Agonist / Unkown
HY-P3050 Helospectin II Inhibitor / Unkown
HY-P3053 Helospectin I / Unkown
HY-P4015 VIP (1-12), human, porcine, rat, ovine Ligand / Unkown
HY-RS03086 CPAMD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15653 VIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103019AR (±)-Enitociclib (Standard) / Unkown
HY-RS16586 Vip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23021 Vip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vip NCBI NCBI:7432