2. Gene
  3. Bmx - BMX non-receptor tyrosine kinase Gene

Bmx - BMX non-receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Etk; Tyro8; Etk/Bmx

Gene ID: 12169 | Gene type: protein coding

About Bmx

Chromosome X: 162,975,838-163,041,189 reverse strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 137 orthologues, 32 paralogues and is associated with 2 phenotypes. Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM .9) and 22 other tissues.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within apoptotic process; cell adhesion; and phosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Is expressed in several structures, including cardiovascular system; central nervous system; immune system; lung; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Bmx Products(1)

mRNA Protein Name
NM_009759.4 NP_033889.2 cytoplasmic tyrosine-protein kinase BMX

Bmx Protein Structure

PH_Btk

PH_Btk: cd01238 (24 - 150)

SH2_Tec_Bmx

SH2_Tec_Bmx: cd10399 (268 - 373)

PKc_like

PKc_like: cl21453 (391 - 646)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

cytoplasmic tyrosine-protein kinase BMX

TYRO8 protein tyrosine kinase 8

bone marrow tyrosine kinase gene in chromosome X protein homolog

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-130574 MnTE-2-PyP chloride ≥95.0% Phase 2
HY-111553 TAS0728 Inhibitor 99.15% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80002 BMX-IN-1 Inhibitor 99.84% Unkown
HY-101267 CHMFL-BMX-078 Inhibitor ≥98.0% Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-RS01557 BMX Human Pre-designed siRNA Set A / Unkown
HY-RS01558 Bmx Mouse Pre-designed siRNA Set A / Unkown
HY-RS01559 Bmx Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmx NCBI NCBI:660