Bmx - BMX non-receptor tyrosine kinase Gene

Also Known as Etk; Tyro8; Etk/Bmx

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12169

About Bmx

Chromosome X: 162,975,838-163,041,189 reverse strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 137 orthologues, 32 paralogues and is associated with 2 phenotypes. Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM .9) and 22 other tissues.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within apoptotic process; cell adhesion; and phosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Is expressed in several structures, including cardiovascular system; central nervous system; immune system; lung; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Bmx Products (1)

mRNA Protein Name
NM_009759.4 NP_033889.2 cytoplasmic tyrosine-protein kinase BMX

Bmx Protein Structure

PH_Btk

PH_Btk: cd01238 (24 - 150)

SH2_Tec_Bmx

SH2_Tec_Bmx: cd10399 (268 - 373)

PKc_like

PKc_like: cl21453 (391 - 646)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

cytoplasmic tyrosine-protein kinase BMX

  • TYRO8 protein tyrosine kinase 8

  • bone marrow tyrosine kinase gene in chromosome X protein homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-176498 NBM-T-BMX-OS01 99.74% Phase 3
HY-130574 MnTE-2-PyP chloride / Phase 2
HY-139481 TL-895 Inhibitor 99.86% Phase 2
HY-111553 TAS0728 Inhibitor 99.71% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-101267 CHMFL-BMX-078 Inhibitor 98.0% Unkown
HY-183682 AZ14289671 Inhibitor / Unkown
HY-125662A BMX-001 Inhibitor / Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-173057 BMX-IN-3 / Unkown
HY-173280 Brefeldin A 4-O-nicotinate Inhibitor / Unkown
HY-174142 IHMT-15130 Inhibitor / Unkown
HY-182293 BTK-IN-48 Inhibitor / Unkown
HY-182902 IHMT-15137 / Unkown
HY-184005 IHMT-BMX-068 / Unkown
HY-184006 BMX ligand-1 Ligand / Unkown
HY-RS01557 BMX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01558 Bmx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01559 Bmx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmx NCBI NCBI:660