Cdc42 - cell division cycle 42 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12540

Summary

Enables several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to interferon-gamma; filopodium assembly; and positive regulation of phosphatidylinositol 3-kinase activity. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42 Products (2)

mRNA Protein Name
NM_001243769.1 NP_001230698.1 cell division control protein 42 homolog isoform 2
NM_009861.3 NP_033991.1 cell division control protein 42 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
10954424 MGI
enables GTPase activity IDA
IDA: Inferred from direct assay
10699171 MGI
enables GTPase activity IGI
IGI: Inferred from genetic interaction
18838382 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8464478 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21048939 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adherens junction organization IMP
IMP: Inferred from mutant phenotype
16892058 MGI
acts upstream of or within cardiac conduction system development IGI
IGI: Inferred from genetic interaction
21690310 MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
31219639 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within dendritic cell migration IGI
IGI: Inferred from genetic interaction
22461490 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25851601 MGI
involved in embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
31219639 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
24792215 MGI
involved in endothelin receptor signaling pathway involved in heart process IMP
IMP: Inferred from mutant phenotype
31219639 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
24792215 MGI
acts upstream of or within establishment or maintenance of apical/basal cell polarity IMP
IMP: Inferred from mutant phenotype
16892058 MGI
acts upstream of or within filopodium assembly IDA
IDA: Inferred from direct assay
10699171 MGI
acts upstream of or within heart contraction IGI
IGI: Inferred from genetic interaction
21690310 MGI
involved in heart process IMP
IMP: Inferred from mutant phenotype
25197047 MGI
acts upstream of or within neuron fate determination IMP
IMP: Inferred from mutant phenotype
16892058 MGI
acts upstream of or within nuclear migration IMP
IMP: Inferred from mutant phenotype
15882626 MGI
acts upstream of or within nucleus localization IMP
IMP: Inferred from mutant phenotype
16892058 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
19244314 MGI
involved in positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
23219958 MGI
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
22494997 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 MGI
involved in positive regulation of pinocytosis IMP
IMP: Inferred from mutant phenotype
24792215 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
16621792 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
31219639 MGI
acts upstream of or within regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
16892058 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
25851601 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
19244314 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16892058 MGI
is active in cell leading edge IDA
IDA: Inferred from direct assay
31219639 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
19796622 MGI
located in cell projection IDA
IDA: Inferred from direct assay
15728722 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15775979 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21828338 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25851601 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25851601 MGI
located in leading edge membrane IDA
IDA: Inferred from direct assay
22461490 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21828338 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
33531495 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
33531495 MGI
located in storage vacuole IDA
IDA: Inferred from direct assay
21828338 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cell division control protein 42 homolog

  • G25K GTP-binding protein

  • cell division cycle 42 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-I0400 N-Acetylneuraminic acid 99.95% Phase 1
HY-112842 MBQ-167 Inhibitor 99.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-12874 CASIN 99.89% Unkown
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-111424 BDP9066 Inhibitor 98.18% Unkown
HY-13963 ZCL278 Inhibitor 98.49% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-N2438 Methylophiopogonanone B 99.84% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-136383 AZA1 98.17% Unkown
HY-136379 CID44216842 Inhibitor 99.84% Unkown
HY-B0580B (R)-Ketorolac Inhibitor 99.65% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-15031 l-Naproxen Inhibitor 99.63% Unkown
HY-149464 ARN22089 Inhibitor 98.18% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-111424A (R)-BDP9066 Inhibitor 98.49% Unkown
HY-121667 Scaff10-8 Inhibitor 99.11% Unkown
HY-RS02300 CDC42 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116269 AZA197 98.71% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-170327 ZCL279 Inhibitor 99.20% Unkown
HY-RS23116 Cdc42 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111423 BDP8900 Inhibitor / Unkown
HY-13963S ZCL278-13C / Unkown
HY-149921 Antiangiogenic agent 3 Inhibitor / Unkown
HY-161736 ARN25499 Inhibitor / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-183246 Rac/Cdc42-IN-1 Inhibitor / Unkown
HY-RS02301 CDC42BPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02302 CDC42BPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02303 CDC42EP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02304 CDC42EP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02305 CDC42EP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167828 ARN25062 Inhibitor / Unkown
HY-N15267 Ovalitenone Inhibitor / Unkown
HY-N16021 4A-MPLA ammonium / Unkown
HY-RS16681 Cdc42 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc42 NCBI NCBI:998