2. Gene
  3. CPD - carboxypeptidase D Gene

CPD - carboxypeptidase D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GP180

Gene ID: 1362 | Gene type: protein coding

About CPD

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,378,927-30,469,989 (from NCBI)

This gene has 10 transcripts (splice variants), 219 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 44.8), gall bladder (RPKM 23.6) and 24 other tissues.

Summary

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type Carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type Carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

CPD Products(2)

mRNA Protein Name
NM_001199775.1 NP_001186704.1 carboxypeptidase D isoform 2
NM_001304.5 NP_001295.2 carboxypeptidase D isoform 1 precursor

CPD Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (71 - 371)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (384 - 459)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (510 - 782)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (796 - 870)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (941 - 1201)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (1215 - 1285)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1380 a.a.
Protein Preferred Names Protein Names

carboxypeptidase D

metallocarboxypeptidase D

Related Diseases

Diseases Alias
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153386 CPD-1224 Inhibitor 99.24% Unkown
HY-112338 C188 Inhibitor ≥97.0% Unkown
HY-163333 αvβ5 integrin-IN-2 / Unkown
HY-134621 P300-IN-1 Inhibitor / Unkown
HY-143498 ERCC1-XPF-IN-1 Inhibitor / Unkown
HY-144028 Pan-Trk-IN-2 Inhibitor / Unkown
HY-147310 CU-CPD107 Agonist / Unkown
HY-153441 AXL-IN-15 Inhibitor / Unkown
HY-158009 SGF29-IN-1 Inhibitor / Unkown
HY-158142 PROTAC TYK2 degrader-1 Degrader / Unkown
HY-163533 CPD-002 Inhibitor / Unkown
HY-N7893 Ebracteolata cpd B / Unkown
HY-P4523 FA-Ala-Arg / Unkown
HY-RS03089 CPD Human Pre-designed siRNA Set A / Unkown
HY-W471937 α1B-AR antagonist 1 Antagonist / Unkown
HY-160167 BTK-IN-30 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPD VGNC VGNC:39551
Bos taurus CPD VGNC VGNC:27647
Rattus norvegicus CPD RGD RGD:2393
Mus musculus CPD MGD MGI:107265
Felis catus CPD VGNC VGNC:61119
Macaca mulatta CPD VGNC VGNC:99139