CPD - carboxypeptidase D Gene

Also Known as GP180

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1362

About CPD

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,378,927-30,469,989 (from NCBI)

This gene has 10 transcripts (splice variants), 219 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 44.8), gall bladder (RPKM 23.6) and 24 other tissues.

Summary

The metallocarboxypeptidase family of Enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type Carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type Carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

CPD Products (2)

mRNA Protein Name
NM_001199775.1 NP_001186704.1 carboxypeptidase D isoform 2
NM_001304.5 NP_001295.2 carboxypeptidase D isoform 1 precursor

CPD Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (71 - 371)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (384 - 459)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (510 - 782)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (796 - 870)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (941 - 1201)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (1215 - 1285)

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  • 300
  • 600
  • 900
  • 1200
  • 1380 a.a.
Protein Preferred Names Protein Names

carboxypeptidase D

  • metallocarboxypeptidase D

Related Diseases

Diseases Alias
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-158009 SGF29-IN-1 Inhibitor 98.0% Unkown
HY-153386 CPD-1224 Inhibitor 99.83% Unkown
HY-168664 CPD-39 Degrader 98.06% Unkown
HY-20240 tert-Butyl (6-aminospiro[3.3]heptan-2-yl)carbamate 99.13% Unkown
HY-22391 tert-Butyl (7-aminoheptyl)carbamate ≥98.0% Unkown
HY-168660 CPD-10 98.59% Unkown
HY-143498 ERCC1-XPF-IN-1 Inhibitor 99.37% Unkown
HY-163705 BR-cpd7 Degrader 98.01% Unkown
HY-112338 C188 98.29% Unkown
HY-147310 CU-CPD107 Agonist 98.07% Unkown
HY-W585819 3-Chloropropane-1,2-diol dipalmitate 98.0% Unkown
HY-171786 CDK12-IN-8 Inhibitor 99.52% Unkown
HY-174416 Smurf1-IN-5 Inhibitor 99.01% Unkown
HY-134621 P300-IN-1 Inhibitor / Unkown
HY-144028 Pan-Trk-IN-2 Inhibitor / Unkown
HY-153441 AXL-IN-15 Inhibitor / Unkown
HY-158340 TYK2 ligand 1 Inhibitor / Unkown
HY-161606 PARP-1/2/7-IN-1 Inhibitor / Unkown
HY-161607 PARP7-IN-21 Inhibitor / Unkown
HY-163533 CPD-002 Inhibitor / Unkown
HY-168662 Palbociclib-CH2COOH Control / Unkown
HY-169059 Ferroptosis-IN-12 Inhibitor / Unkown
HY-172455 TREK inhibitor-3 Inhibitor / Unkown
HY-174991 CPD-2828 Inhibitor / Unkown
HY-176927 ADC-VI / Unkown
HY-178488 BRM/BRG1 ATP-IN-7 Inhibitor / Unkown
HY-178490 BRM/BRG1 ATP-IN-8 Inhibitor / Unkown
HY-N7893 Ebracteolata cpd B 99.96% Unkown
HY-P4523 FA-Ala-Arg / Unkown
HY-P4914 Sex Pheromone Inhibitor iPD1 Inhibitor / Unkown
HY-RS03089 CPD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06284 HOMER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W471937 α1B-AR antagonist 1 Antagonist / Unkown
HY-116470 Mps1/TTK-IN-1 Inhibitor / Unkown
HY-168663 E3 Ligase Ligand-linker Conjugate 131 / Unkown
HY-168668 E3 Ligase Ligand-linker Conjugate 132 / Unkown
HY-179364 PLTP-IN-1 / Unkown
HY-RS18891 Cpd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25382 Cpd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W585819R 3-Chloropropane-1,2-diol dipalmitate (Standard) / Unkown
HY-W585819S 3-Chloropropane-1,2-diol dipalmitate-13C3 / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99641 Gilvetmab Inhibitor 99.37% Unkown
HY-P990114 Anti-Canine PD-L1/B7-H1 Antibody (JC071) Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPD VGNC VGNC:39551
Bos taurus CPD VGNC VGNC:27647
Rattus norvegicus CPD RGD RGD:2393
Mus musculus CPD MGD MGI:107265
Felis catus CPD VGNC VGNC:61119
Macaca mulatta CPD VGNC VGNC:99139
Others CPD NCBI