Tlr3 - toll-like receptor 3 Gene

Mus musculus

Gene ID: 142980 | Gene type: protein coding

About Tlr3

Chromosome 8: 45,848,702-45,864,117 reverse strand.GRCm39:CM001001.3

This gene has 9 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 50 phenotypes. Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues.

Summary

Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlr3 Products(3)

mRNA	Protein	Name
NM_126166.5	NP_569054.2	toll-like receptor 3 precursor
NM_001357317.1	NP_001344246.1	toll-like receptor 3 precursor
NM_001357316.1	NP_001344245.1	toll-like receptor 3 precursor

Tlr3 Protein Structure

LRR_RI

PLN00113

LRR_RI

PPP1R42

LRR_RI

LRR_1

LRR_RI

LRRCT

Tlr3_TMD

TIR

0
200
400
600
800
905 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 3

Recombinant Tlr3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73587	TLR3 Protein, Mouse (sf9, His)	Q99MB1 (C29-L705)	≥95%
HY-P73588	TLR3 Protein, Mouse (705a.a, HEK293, His)	Q99MB1 (M1-L705)	≥95%
HY-P78362	TLR3 Protein, Mouse (681a.a, HEK293, His)	Q99MB1 (T25-L705)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108473	CU-CPT 4a	Inhibitor	98.91%	Unkown
HY-135748	Polyinosinic-polycytidylic acid sodium	Agonist	≥99.0%	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-134958	Polyinosinic-polycytidylic acid potassium	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr3	NCBI	NCBI:7098
Macaca fascicularis	Tlr3	NCBI	NCBI:102138517

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