Tlr3 - toll-like receptor 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 142980

About Tlr3

Chromosome 8: 45,848,702-45,864,117 reverse strand.GRCm39:CM001001.3

This gene has 9 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 50 phenotypes. Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues.

Summary

Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlr3 Products (3)

mRNA Protein Name
NM_126166.5 NP_569054.2 toll-like receptor 3 precursor
NM_001357317.1 NP_001344246.1 toll-like receptor 3 precursor
NM_001357316.1 NP_001344245.1 toll-like receptor 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
16260493 MGI
enables pattern recognition receptor activity IGI
IGI: Inferred from genetic interaction
16260493 MGI
enables pattern recognition receptor activity IMP
IMP: Inferred from mutant phenotype
12855817 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17452530 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
27830702 MGI
enables ubiquitin-like protein ligase binding IPI
IPI: Inferred from physical interaction
31076723 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
16260493 MGI
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
acts upstream of or within cellular response to exogenous dsRNA IDA
IDA: Inferred from direct assay
28970238 MGI
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
18802055 MGI
acts upstream of chemokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
11607032 MGI
acts upstream of or within defense response to virus IGI
IGI: Inferred from genetic interaction
18250457 MGI
involved in inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 MGI
acts upstream of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of macrophage cytokine production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
16260493 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
26934179 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19734906 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16260493 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
16260493 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
27830702 MGI
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15356140 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
15356140 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
17008311 MGI
acts upstream of or within positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18802055 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
15356140 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17008311 MGI
acts upstream of or within positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
18207576 MGI
acts upstream of or within positive regulation of type III interferon production IDA
IDA: Inferred from direct assay
18207576 MGI
acts upstream of or within regulation of dendritic cell cytokine production IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
14993594 MGI
acts upstream of type I interferon production IDA
IDA: Inferred from direct assay
18207576 MGI
acts upstream of type III interferon production IDA
IDA: Inferred from direct assay
18207576 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
27830702 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr3 Protein Structure

LRR_RI

LRR_RI: sd00033 (36 - 52)

LRR_RI

LRR_RI: sd00033 (53 - 76)

PLN00113

PLN00113: cl33413 (69 - 542)

LRR_RI

LRR_RI: sd00033 (77 - 100)

LRR_RI

LRR_RI: sd00033 (101 - 124)

LRR_RI

LRR_RI: sd00033 (125 - 148)

LRR_RI

LRR_RI: sd00033 (149 - 198)

LRR_RI

LRR_RI: sd00033 (199 - 249)

LRR_RI

LRR_RI: sd00033 (250 - 275)

LRR_RI

LRR_RI: sd00033 (276 - 299)

LRR_RI

LRR_RI: sd00033 (300 - 323)

LRR_RI

LRR_RI: sd00033 (324 - 380)

LRR_RI

LRR_RI: sd00033 (381 - 432)

LRR_RI

LRR_RI: sd00033 (433 - 457)

LRR_RI

LRR_RI: sd00033 (458 - 481)

LRR_RI

LRR_RI: sd00033 (482 - 507)

PPP1R42

PPP1R42: cl42388 (502 - 648)

LRR_RI

LRR_RI: sd00033 (508 - 531)

LRR_RI

LRR_RI: sd00033 (532 - 563)

LRR_RI

LRR_RI: sd00033 (564 - 585)

LRR_1

LRR_1: sd00031 (588 - 609)

LRR_RI

LRR_RI: sd00033 (612 - 636)

LRRCT

LRRCT: smart00082 (645 - 697)

Tlr3_TMD

Tlr3_TMD: pfam17968 (698 - 730)

TIR

TIR: smart00255 (755 - 900)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 905 a.a.
Protein Preferred Names Protein Names

toll-like receptor 3

Recombinant Tlr3 Proteins

Cat. No. Product Name Accession Purity
HY-P78362 TLR3 Protein, Mouse (HEK293, His) Q99MB1/NP_569054.2 (T26-L705) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0377 Famotidine Inhibitor 99.85% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-165632 Creatine ethyl ester Activator / Phase 4

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135748 Polyinosinic-polycytidylic acid sodium Agonist 99.40% Unkown
HY-108473 CU-CPT 4a Inhibitor 99.50% Unkown
HY-18325 AN-3485 Inhibitor 97.38% Unkown
HY-135748A Poly (I:C):Kanamycin (1:1) sodium Agonist 99.0% Unkown
HY-101929 CU-CPT17e Agonist 98.67% Unkown
HY-114592 M199 Inhibitor 98.55% Unkown
HY-176192 SMU-14a Inhibitor / Unkown
HY-183313 IAV-IN-5 Inhibitor / Unkown
HY-183079 ENDO12 Inhibitor / Unkown
HY-W777002 Famotidine-13C3 Inhibitor / Unkown
HY-134958 Polyinosinic-polycytidylic acid potassium Agonist / Unkown
HY-B0377G Famotidine (GMP) Inhibitor / Unkown
HY-B0377S Famotidine-13C,d3 Inhibitor / Unkown
HY-W707517 Famotidine-d4 Inhibitor / Unkown
HY-B0377A Famotidine hydrochloride Inhibitor / Unkown
HY-W682115 Poly(C) Activator / Unkown
HY-B0377S1 Famotidine-13C Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr3 NCBI NCBI:7098