Gpc3 - glypican 3 Gene

Also Known as OCI-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14734

Summary

Predicted to enable peptidyl-dipeptidase inhibitor activity. Involved in mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including animal organ development; positive regulation of transport; and regulation of signal transduction. Located in lysosome and plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including branchial arch; future brain; lower jaw; reproductive system; and urinary system. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Apr 2022]

Gpc3 Products (1)

mRNA Protein Name
NM_016697.3 NP_057906.2 glypican-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18343214 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
15537637 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9853964 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
10964473 MGI
acts upstream of or within body morphogenesis IMP
IMP: Inferred from mutant phenotype
18477453 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
15936336 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
15925496 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15537637 MGI
acts upstream of or within cell proliferation involved in kidney development IMP
IMP: Inferred from mutant phenotype
11180950 MGI
acts upstream of or within cell proliferation involved in metanephros development IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
19733558 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
10964473 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of growth IMP
IMP: Inferred from mutant phenotype
15537637 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10402475 MGI
involved in mesenchymal cell proliferation involved in ureteric bud development IMP
IMP: Inferred from mutant phenotype
15925496 MGI
acts upstream of or within mesonephric duct morphogenesis IMP
IMP: Inferred from mutant phenotype
11180950 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15537637 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15925496 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of or within negative regulation of growth IMP
IMP: Inferred from mutant phenotype
11846487 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
19590577 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
18477453 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15936336 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
15925496 MGI
acts upstream of or within positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
18343214 MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
15537637 MGI
acts upstream of or within positive regulation of endocytosis IDA
IDA: Inferred from direct assay
18477453 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
18477453 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19733558 MGI
acts upstream of or within regulation of growth IGI
IGI: Inferred from genetic interaction
19590577 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
10402475 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19733558 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
18477453 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18343214 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
18477453 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glypican-3

Recombinant Gpc3 Proteins

Cat. No. Product Name Accession Purity
HY-P70872 Glypican-3/GPC3 Protein, Mouse (HEK293, His) Q8CFZ4 (Q25-M557) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73078 Glypican-3/GPC3 Protein, Mouse (sf9, His) Q8CFZ4 (Q25-P558) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.99% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99013 Codrituzumab Inhibitor 99.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10888A GPC3 targeting peptide 1 TFA 99.40% Unkown
HY-W1124925 DOTA-GPC3 targeting peptide 2 Ligand 98.83% Unkown
HY-182099 DSPE-PEG1000-DHLASLWWGTEL / Unkown
HY-182099A DSPE-PEG2000-DHLASLWWGTEL / Unkown
HY-182099B DSPE-PEG3400-DHLASLWWGTEL / Unkown
HY-182099C DSPE-PEG5000-DHLASLWWGTEL / Unkown
HY-185742 ZW-251 Inhibitor / Unkown
HY-P11618 10P3Me Ligand / Unkown
HY-RS05628 GPC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10888 GPC3 targeting peptide 1 / Unkown
HY-RS16630 Gpc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23065 Gpc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990840 Anti-GPC3 Antibody (YP7) Inhibitor ≥95.0% Unkown
HY-P990841 Anti-pan-Glypican Antibody (HS20) Inhibitor 99.44% Unkown
HY-P992011 CAT-07 Inhibitor / Unkown
HY-P992457 SAR444200 Activator / Unkown
HY-P992514 ZW-251 Antibody Inhibitor / Unkown
HY-P991448 MDX-1414 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpc3 NCBI NCBI:2719